Kylian Mbappé saw a penalty saved as Liverpool beat Real Madrid 2-0 on Wednesday to inflict a third Champions League defeat in five matches on the holders.
Alexis Mac Allister and Cody Gakpo scored the goals in the second half as the Reds maintained their perfect record to return to the top of the table.
Mohamed Salah also fired wide from the spot, but it mattered little as Liverpool secured a 17th win in Arne Slot's first 19 games in charge.
Slot has already achieved what Jurgen Klopp could not as Liverpool boss by slaying the Spanish giants.
Liverpool had a score to settle with Madrid, who were unbeaten in eight previous meetings between the sides, including Champions League finals against Klopp's men in 2018 and 2022.
Defeat sends Carlo Ancelotti's side tumbling down to 24th in the table.
Only the top 24 progress to the knockout stage with the top eight advancing directly to the last 16.
Liverpool are well on course to do just that and the confidence coursing through a side also eight points clear at the top of the Premier League was in evidence throughout in front of a highly-charged Anfield crowd.
Madrid were hamstrung by a lengthy injury list and made the trip to England without Vinicius Junior, Rodrygo, Dani Carvajal, Eder Militao, Aurelien Tchouameni and David Alaba.
Young centre-back Raul Asencio has been pressed into action by those absences and he made a vital goal-line clearance on four minutes. (AFP)