The Reds take on Bodo/Glimt in our fifth Europa League match of the season, for what is our first-ever competitive meeting with Norwegian opposition.
Of course it is also a historic night as Amorim takes charge of a maiden game in M16 and he has made six changes to the side which drew 1-1 at Ipswich on Sunday.
Tyrell Malacia makes his first senior Reds appearance in 550 days, a fortnight on from completing 45 minutes for our Under-21s at Huddersfield.
The Dutch defender has been sidelined since the end of the 2022/23 campaign and has been working diligently towards a return at Carrington for a while now.
Antony is in the starting XI for only the second time this season and could be a candidate to play at right wing-back - if Amorim plays with the three-at-the-back system - while Mason Mount and Manuel Ugarte line up in midfield.
Lisandro Martinez is back in the team, following a one-game injury absence, and Rasmus Hojlund leads the line for United.
Jonny Evans is not in the squad at all, while Amad, Casemiro, Diogo Dalot, Christian Eriksen and our goalscorer at Portman Road, Marcus Rashford, drop to the bench.
UNITED: Onana, Mazraoui, De Ligt, Martinez, Antony, Ugarte, Fernandes (c), Malacia, Mount, Garnacho, Hojlund.
Substitutes: Bayindir, Heaton, Dalot, Shaw, Eriksen, Casemiro, Mainoo, Amad, Zirkzee, Rashford.