Burn is immediately restored to the line-up after serving a one-match ban. Tonali, meanwhile, starts for the first time since the 2-0 win over Chelsea in the Carabao Cup last month.
The Italian joins Bruno Guimaraes in midfield. Howe faced questions on whether the pair could play together in Friday’s press conference.
“Anything is possible,” Howe said. ”Of course they can. They are two outstanding players. It’s up to me to try and find a solution that works for both players and sees their qualities within the team.
“You can put any player into the team and any combination of players into the team, but it’s got to be to the team’s benefit. It has to be right for both players to showcase their attributes. So, hopefully we can do that.”
Here’s Newcastle United’s starting XI and subs in full: