New Leicester City manager Ruud van Nistelrooy will watch a new-look side with caretaker boss Ben Dawson introducing four new faces and a changed formation.
Dawson has handed Conor Coady and Luke Thomas their first Premier League starts of the season as part of a back five. James Justin, Wout Faes and Caleb Okoli complete the back-line.
Facundo Buonanotte, back from suspension, returns to the 11, while Jordan Ayew also comes in. Victor Kristiansen, the injured Harry Winks, Kasey McAteer and Bilal El Khannouss are the four to drop out of the side.
It looks like it will be a 5-4-1 formation with Buonanotte on the right and Ayew on the left, with Wilfred Ndidi and Boubakary Soumare in the middle. But equally it could be a midfield three with Buonanotte central, and then Ayew joining Jamie Vardy up front.
The change in formation looks like a defensive one, with City only keeping one clean sheet this season and conceding the third-highest tally of goals. Brentford have the best home record in the division, with five wins and one draw at the Gtech Community Stadium so far this campaign.
**City (5-4-1):** Hermansen; Justin, Faes, Coady, Okoli, Thomas; Buonanotte, Ndidi, Soumare, Ayew; Vardy. **Subs:** Ward, Vestergaard, Kristiansen, Choudhury, Skipp, El Khannouss, De Cordova-Reid, Mavididi, Daka.