Steve Cuss' side come off the back of a convincing 4-0 win over AFC Porchester in the Adobe FA Cup.
They have only lost one game in all competitions all season and will be looking to extend an unbeaten run of 12.
Cambridge United play at the same level, but in the National League Division One South East and sit in 9th place, whilst the Cherries are currently top of the Division One South West.
Looking ahead to the game, Cuss said: "We've got Cambridge at home, and we know it's going to be a difficult game."
He added: "They don't let in a lot of goals, they are good defensively, and we see it as a real difficult tie and a tricky challenge."
On the team's success in the competition, Cuss said: "We're really excited by the game as it's an important part of the season where there are lots of important league games coming up and cup competitions."
Cuss added: "We've never been this far in the national competition as well, so we are pushing those boundaries as a squad which I'm delighted with."