Goodison Park is a tough place to go and Wolves will need to manage the occasion.
On top of that, they will likely need to be solid at the back and strong from set pieces.
With that in mind, I predict a switch to a back five with Mario Lemima no longer playing in defence.
Jose Sa, despite his clangers at the weekend, will keep his place in my opinion.
O'Neil could go with a back five and choose to keep a senior central defender on the bench, but I think Santi Bueno and Craig Dawson will both come back into the team, with Matt Doherty replacing the suspended Nelson Semedo.
Predicted Wolves XI
Predicted Wolves XI
Moving Lemina back into midfield probably means dropping a midfielder, with O'Neil seemingly keen not to play three in that position, meaning Andre probably misses out.
Matheus Cunha and Jorgen Strand Larsen are expected to play, once again leaving that final attacking spot up for grabs.
Hwang Hee-chan did very little off the bench at the weekend and his minutes have been limited on his return from injury, but I expect O'Neil to be keen to get him into the side as soon as possible and this game could suit him.