Police were called to the collision in Wherstead Road just before 4.40pm on Tuesday.
Two mopeds and a car were involved in the incident which blocked the road in both directions as tens of thousands were starting to plan to travel to Portman Road for the Ipswich Town vs Crystal Palace Premier League match.
Paramedics were also on the scene attending to a driver with minor shoulder injuries.
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A spokesman for the East of England Ambulance Service said: "We were called just after 4.30pm to a road traffic collision in Wherstead Road in Ipswich.
"Two ambulances, two rapid response vehicles and an ambulance officer vehicle were sent to the scene.
"Two patients were transported to Ipswich Hospital for treatment."
The incident was cleared and the road reopened later that night.