The club released a statement after rumours begun to circulate on social media.
It read: "West Ham United can confirm striker Michail Antonio has today been involved in a road traffic accident.
"The thoughts and prayers of everyone at the Club are with Michail, his family and friends at this time. The Club will issue an update in due course."
Pictures on social media showed a smashed up Ferrari, allegedly in the aftermath of the incident.
Wolves are due to face West Ham United on Monday night at the London Stadium.
There is no indication that the game would be in doubt at this stage.