Just days before his fourth birthday, Santiago was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children.
He began chemotherapy the next day, and the outlook was promising – disease-free survival rates for B-ALL are among the highest for paediatric cancers, at 80 to 85 per cent. However, limited progress has been made over the last 15 years, and relapsed B-ALL remains a leading cause of cancer death among children.
Seeking to explore all options, Santiago's parents enrolled him in a Children's Oncology Group clinical trial led by scientists at The Hospital for Sick Children (SickKids) and Seattle Children's Hospital. The trial, which included over two hundred sites across four countries, combined standard chemotherapy with two cycles of blinatumomab, an immunotherapy already used for children with relapsed B-ALL.
Early study results were so promising that the trial closed early, with findings published in the New England Journal of Medicine showing a striking 61 per cent reduction in the risk of B-ALL relapse or death for those who received both chemotherapy and blinatumomab.
These breakthrough data showing a significant improvement in disease-free survival are set to bring a tremendous clinical benefit to nearly all children with newly diagnosed B-ALL. This is changing the standard of care for children with B-ALL around the world."
Dr. Sumit Gupta, study co-lead, Oncologist and Associate Scientist in the Child Health Evaluative Sciences program at SickKids
Reducing relapse – and side effects
Before he joined the trial, Santiago received a combination therapy of steroids and chemotherapy, already personalized based on a genetic analysis of his leukemia cells showing which medications would be most effective for him.
"We knew the treatment was necessary, but the weight gain and loss of independence from the steroids were heartbreaking to watch," says Beatriz, Santiago's mother. "The first round of blinatumomab had its own side effects, but it was nothing compared to his previous treatment and it gave him so much more freedom to be a regular kid."
Unlike chemotherapy, immunotherapies like blinatumomab use the body's own immune system to fight cancer by teaching the immune system to target cancer cells. For children like Santiago with an average risk of relapse, the study showed that after three years, the disease-free survival rate increased to 97.5 per cent, compared to 90 per cent with chemotherapy alone. For children with a higher risk of relapse, receiving blinatumomab in addition to chemotherapy increased the disease-free survival rate from 85 per cent to over 94 per cent.
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"These findings underscore the progress made with blinatumomab in preventing relapse and support its role as a critical addition to current therapeutic strategies," says study co-lead Dr. Rachel Rau, paediatric hematologist-oncologist at Seattle Children's Hospital and associate professor of pediatrics at the University of Washington.
A new era of childhood cancer treatment
The findings published today included 1,440 children from Canada, the U.S., Australia and New Zealand, and the results mark a significant milestone in the fight against childhood cancer. As a member of the Children's Oncology Group, SickKids is working with more than 11,000 experts worldwide, to advance over 100 active clinical-translational trials at any given time. Of these active trials, those for children with B-ALL are being paused to introduce blinatumomab into their study designs as well.
"This new combination treatment is set to become the new standard of care for these patients, potentially saving many lives and reducing the fear and health impacts associated with relapse," says Sumit, who is also an Associate Professor at the University of Toronto. "We are now designing the next generation of studies to see whether we can safely remove some of the chemotherapy that currently makes up standard treatment, while maintaining these outstanding success rates. It's an incredibly exciting time to be in this field as we start to try to decrease the short and long-term side effects associated with treatment."
Nine months after his first diagnosis, Santiago is excited to finally start school in the new year, trading in his shark backpack for a backpack he chose before his diagnosis. He will continue to take a low-intensity chemotherapy regimen intended to help prevent leukemia from returning, but his family is excited to start this new chapter together.
"This is Santiago's journey. My job is to hold his hand and help make sure he gets the best care possible," says Beatriz.
The study was funded by the U.S. National Institutes of Health/National Cancer Institute and St. Baldrick's Foundation.
The Hospital for Sick Children
Journal reference:
Gupta, S., et al. (2024). Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children. New England Journal of Medicine. doi.org/10.1056/nejmoa2411680.