Liverpool's first-choice goalkeeper Alisson Becker has been warned that he faces a challenging return to the starting line-up as he steps in for Caoimhin Kelleher.
After more than two months out, Alisson is poised to make his comeback in Liverpool's Champions League match against Girona in Spain this Tuesday evening.
The Brazilian has been sidelined since sustaining a hamstring injury during the latter stages of Liverpool's 1-0 victory over Crystal Palace in early October.
In his absence, back-up keeper Kelleher has delivered a series of commendable displays, contributing to Liverpool's lead in both the Premier League and Champions League standings.
However, Kelleher did play a part in conceding a late goal in the 3-3 draw with Newcastle United last Wednesday. Slot acknowledged the difficulty Alisson will face in surpassing Kelleher's recent form, especially after the Irishman's three consecutive clean sheets in the Champions League.
"Alisson is fit, yes," Slot confirmed. "I think it speaks for itself if you can play Alisson, who has been so outstanding for this club for so many years and for the Brazil national team. It is definitely nice to have him back and to have him available.
"But if you look at how his replacement did, it is not going to be easy to do it better. We expect that will be the same and the margins could be better.
"But Caoimh did also so well that we can say that we have two very good goalkeepers. For so many years, Alisson has been so outstanding for this club that we are expecting and hoping he will do the same in the coming weeks and months."
While Alisson is back in contention, Diogo Jota hasn't travelled to Girona despite featuring in open training on Monday in Kirkby.
Federico Chiesa and Tyler Morton also remained on Merseyside due to illness and a minor knock respectively, with defenders Ibrahima Konate, Conor Bradley and Kostas Tsimikas also out.
Alexis Mac Allister is serving a one-match European suspension. Liverpool have taken only a 19-man squad to Spain that also includes third-choice goalkeeper Vitezslav Jaros, 20 year old midfielder James McConnell and Academy left-back James Norris.
With the Goodison derby against Everton called off on Saturday due to inclement weather, the Reds haven't been in action for almost a week and Slot has hinted he has no option but to go strong with his starting line-up.
"Everybody (available) is really fit because we skipped the game on Saturday," he said.
"Now there is no reason to rotate from the last match. Maybe there is a reason for the upcoming match (against Fulham at home on Saturday in the Premier League) but there are three days in between to that one. We will start like all the other games with a very good team."