The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.
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Fig. 1: Hand2 regulates pdgfra expression to mediate early cardiogenesis.
References
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This is a summary of: Xu, Y. et al. PDGFRA is a conserved HAND2 effector during early cardiac development. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00574-1 (2024).
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DNA-binding-deficient Hand2 dimerizes with Tcf3a to control zebrafish cardiogenesis. Nat Cardiovasc Res (2024). https://doi.org/10.1038/s44161-024-00589-8
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Published:10 December 2024
DOI:https://doi.org/10.1038/s44161-024-00589-8
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