Ruben Amorim welcomed a trio of injured players back to training on Wednesday morning and will be hoping for further good news as his side look to end their run of two matches without a win.
Following their weekend defeat to Nottingham Forest, Amorim is expected to rotate his squad once again, with Tyrell Malacia, Mason Mount and Marcus Rashford all contenders to come into the starting line up.
Here is how we think United should line up when they return to Europa League action against Viktoria Plzen.
Manchester United will make changes against Viktoria Plzen
1. Manchester United will make changes against Viktoria Plzen
Manchester United will make changes against Viktoria Plzen | line-up builder Photo: line-up builder
He was poor against Forest last weekend but Onana should keep his place in goal for this important match.
2. GK - Andre Onana
He was poor against Forest last weekend but Onana should keep his place in goal for this important match. | Getty Images
Yoro needs as much playing time as possible after so long out and should start against Plzen.
3. CB - Leny Yoro
Yoro needs as much playing time as possible after so long out and should start against Plzen. | Getty Images
Maguire has been more effective at centre-back than Matthijs de Ligt in recent weeks and should start this one.
4. CB - Harry Maguire
Maguire has been more effective at centre-back than Matthijs de Ligt in recent weeks and should start this one. | Manchester United via Getty Images