Inflammasomes induce pyroptosis and, through poorly defined mechanisms, promote adaptive immune responses. High-resolution imaging of the explosive morphology of pyroptosis showed that minutes before rupture, gasdermin D instructs the cell to extend filopodia. These structures mark the corpses for recognition by the antigen-sampling receptor CLEC9A on dendritic cells.
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Fig. 1: Inflammasomes induce GSDMD-driven filopodial assembly before pyroptotic cell rupture, enabling pyroptotic corpses to stimulate CLEC9A on dendritic cells.
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This is a summary of: Holley, C. L. et al. Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nat. Immunol. https://doi.org/10.1038/s41590-024-02024-3 (2024).
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Pyroptotic corpses are flagged by filopodia to alert dendritic cells. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-02025-2
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Published:12 December 2024
DOI:https://doi.org/10.1038/s41590-024-02025-2
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