With Saints welcoming Tottenham to St Mary's Stadium at 7pm, the company has decided to allow some sailings to depart later.
From Southampton, the 9.05pm Red Jet sailing will now run at 9.30pm, while the 10.30pm crossing will leave at 10.40pm.
Meanwhile, from Cowes, the 9.40pm sailing will depart at 10.05pm and the 11.05pm crossing will leave at 11.10pm, instead.
Red Funnel said the timetable changes are to support Saints fans travelling to and from the game.
There will also be changes on Wednesday (December 18) when Saints face Liverpool in the EFL Cup quarter final.
To accommodate the 8pm kick off , the firm has added an additional Red Jet sailing from Southampton at 11.40pm and from Cowes at 12.15am.
"You can also use our Vehicle Ferry as an alternative", a spokesperson said.