Arsenal take on Crystal Palace at the Emirates Stadium as they hope to put their Premier League struggles aside and progress to the Carabao Cup semi-final. The Gunners have been given one of the more favourable draws.
Tottenham take on Manchester United, while Brentford travel to Newcastle. Liverpool meanwhile have a more expectant tie with bottom-of-the-league Southampton.
Riccardo Calafiori, Takehiro Tomiyasu and Ben White are all expected to miss the game, but the positive news is Declan Rice should make it. However, there are question marks over some lesser-used players like Kieran Tierney and Raheem Sterling and whether they will get an opportunity to play.
This is a strange game in the sense that the Gunners will travel to Crystal Palace for a rematch in the league in just three days. Daniel Munoz, the Eagles’ left-back, however is suspended for yellow card accumulation in both matches.
You can follow all the action from the Emirates Stadium with football.london's Arsenal correspondents Tom Canton and Kaya Kaynak in our live blog below. Updates to follow…