Tottenham and Manchester United fans are being asked to plan ahead due to train service changes.
Engineering work will mean that Greater Anglia services will not call at Straford.
Services that normally run between Hertford East and Stratford will run to and from London Liverpool Street.
Passengers should use Central Line services between Liverpool Street and Stratford and those travelling to Northumberland Park are advised not to change at Stratford.
Services between Meridian Water and Stratford will not run.
Other train services will be disrupted on the Cambridge line with buses operating to get passengers to their destination.
“Greater Anglia services are expected to be very busy both before and after the match and customers are advised to avoid using Stratford station.
Canute Tyndale, Events Delivery Manager, Greater Anglia