Team news
Tottenham trio James Maddison, Destiny Udogie and goalkeeper Guglielmo Vicario are all fit again and available for selection.
Brennan Johnson, Wilson Odobert and Timo Werner are back in various stages of training, while Cristian Romero, Dominic Solanke and Micky van de Ven are thought to be a few weeks away from a return.
Manchester United head coach Ruben Amorim admitted he was forced to draft in academy players to train with the senior squad this week due to injury and illness issues.
Amorim did not name the players affected but Altay Bayindir, Jonny Evans and Mason Mount all missed the FA Cup win over Leicester last Friday due to injury.
Match facts
Head-to-head
Tottenham are unbeaten in the five most recent clashes with Manchester United, winning three and drawing two.
The Lilywhites are seeking to complete a league double over the Red Devils for the first time since the 1989-90 season.
United have conceded at least twice in each of their last four Premier League games against Spurs.
Tottenham Hotspur
Tottenham are winless in seven Premier League home games, drawing two and losing five.
After beating Brentford 2-0 in their last league outing, Spurs are seeking back-to-back league wins for the first time since September, when they defeated Brentford and then Manchester United.
Ange Postecoglou is vying to become just the fourth manager to remain unbeaten in his first four Premier League meetings with Manchester United, emulating Unai Emery, Ruud Gullit and Nuno Espirito Santo.
Son Heung-min provided his 69th Premier League assist in his last outing against Brentford, the most by a Tottenham player in the competition's history.
Archie Gray is one of just three players aged 18 or under to have made 25 starts for a club in Europe's top five leagues this season, joining Barcelona's Lamine Yamal and Pau Cubarsi.
Manchester United
Manchester United have won four of their past five games in all competitions, losing the other.
They are unbeaten in four away matches in league and cup, winning two and drawing two since a 2-0 defeat at Wolves on Boxing Day.
United have accrued just 14 points from a possible 39 since Ruben Amorim took charge in November - only five sides have picked up fewer in that time.
The Red Devils have conceded 32 goals in 20 fixtures across all competitions since Amorim took charge, at an average of 1.6 per match.
Amad Diallo is the club's top Premier League scorer this season with six goals.
Related topics
Manchester United
Premier League
Tottenham Hotspur
Football