Jackson was initially booked by referee John Brooks despite thrusting his elbow into the face of Newcastle defender Sven Botman.
A VAR check resulted in Brooks being instructed to review the incident on his pitchside monitor, with the referee quickly overturning his initial decision and issuing a straight red card.
Eddie Howe felt Jackson’s use of the elbow was a clear red-card offence, but Maresca claimed the passionate reaction of the home support was a factor in Brooks’ decision to upgrade his initial booking.
“For sure, the red card affected the game,” said the Chelsea boss. “Against this team (Newcastle), in this stadium, it’s already complicated and if you give them one extra player, it’s difficult.
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“Overall, I think, especially in the second half, we created big chances even with ten players, when it’s not easy.
“If the referee decides a red card, it’s a red card, but in this stadium, sometimes it’s the noise decides if it’s a foul or not.
“I didn't speak to Nico, it’s not the moment. In the next day, we’ll speak with Nico.”
With Chelsea battling with Newcastle, Arsenal, Manchester City, Nottingham Forest and Aston Villa for a Champions League place, Jackson will now be suspended for his side’s final two games of the season against Manchester United and Forest.
“The season for him (Jackson) is finished,” said Maresca. “He’s our nine, he’s our striker. We will need to find a different solution for the last two games.
“No doubt, 100 per cent he has to learn, especially at this stage of this season where we have two more games.
“What we have to avoid is these kind of things because you need all of your squad available for the next game. It happened, he will be out for the season, and he needs to learn for the future.”