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Bills Toughest Game Not Against Chiefs Predicts NFL Analyst

As part of winning the AFC East for the last five seasons, and being a consistent Super Bowl contender, the Buffalo Bills are walking into the 2025 season with some marquee matchups on the docket.

Buffalo will face the vaunted AFC North that sent three teams to the playoffs last season, and the NFC South. Along the way, they'll take on the division winners from the NFC East, AFC South, and AFC West.

The toughest matchup in Buffalo's way, though (according to Pro Football Network's Kyle Soppe) won't be anyone in their conference. It won't even be the Kansas City Chiefs.

It's the defending champion Philadelphia Eagles.

"Since the start of 2022, Philadelphia is a league-best 16-5 (76.2% win rate) against future playoff teams in the regular season," Soope wrote. "Buffalo’s season will be defined by how they perform in January, though this devoted fanbase could use a confidence-building win prior to the postseason."

Bills quarterback Josh Allen is 0-2 against the Eagles in his career. The first loss came in 2019 in a 31-13 thumper to Carson Wentz and Philly. The two teams put up an instant classic in 2023, though, when Jalen Hurts recorded five touchdowns in a 37-34 overtime win.

Buffalo and Philadelphia are Super Bowl hopefuls going into the 2025 season. Both teams will be circling their respective games on the calendar.

And if their matchup is anything like the 2023 contest was, fans around the league will be in for a treat.

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