The San Francisco 49ers kept each of their original draft picks and welcomed in eleven new players via the 2025 NFL Draft, addressing positions of need on defense early. Free agency departures and cuts made the D-line the top priority for San Francisco, and, as a result, the team dedicated three of its first five picks to fortifying the trenches on the defensive side of the ball. They picked up edge rusher Mykel Williams with the 11th-overall pick, followed up with defensive tackles Alfred Collins in Round 2 and C.J. West in Round 4. All three are proven run-stoppers with lots of pass-rushing upside.