We’ve tracked each rumor about the San Francisco 49ers schedule that hit the internet today. The official schedule is out, so let’s get right into it.
Week 1: September 7 @ Seahawks - Sunday, September 7, 1:05 p.m. PT
The San Francisco 49ers won’t have to travel far for their first road game. The Niners will face an old friend in Sam Darnold. Seattle is projected to regress in 2025. Darnold is a step back from Geno Smith, and the offense replaces DK Metcalf and Tyler Lockett with Cooper Kupp and Marquez Valdes-Scantling.
Week 2: @ Saints - Sunday, September 14, 10:00 a.m. PT
If you’re going to travel across the country early in the year, the week after playing a divisional rival, let it happen against a team without a quarterback. New Orleans has a new head coach and just lost their quarterback to retirement.
Robert Saleh will game-plan against second-rounder Tyler Shough, Spencer Rattler, or former Fresno State quarterback Jake Haener.
How could we forget about the Chase Young revenge game?
Week 3: vs. Cardinals - Sunday, September 21, 1:25 p.m. PT
The 49ers have a soft home opener. They’ll travel back from New Orleans to take on a familiar opponent in the Arizona Cardinals — a team that swept San Francisco in 2024.
The 49ers owe the Cardinals some payback from last season. Arizona overachieved in 2025. They had a strong NFL Draft by adding Walter Nolen and Will Johnson, but the offense should regress. Can the 49ers contain Kyler Murray?
Week 4: vs. Jaguars - Sunday, September 28, 1:05 p.m. PT
Back-to-back home games come here in Week 4, with the 49ers taking on Trevor Lawrence, Travis Hunter, and the Jaguars. Jacksonville could be a sneaky team to watch after a disappointing 2024 season now that they’re fully healthy.
Jacksonville has a tough three-game slate with Cincinnati, Houston, and now San Francisco. That could play in the Niners’ favor.
Week 5: at Rams - Thursday, October 2, 5:15 p.m. PT
The first primetime matchup of the season comes against the reigning NFC West Champions. It's the same team that snatched victory from the jaws of defeat last season. (That’s not entirely true. The season could have gone a lot differently had Deebo Samuel caught the pass that hit him in the chest.)
The Rams are another team that bested the Niners in 2024. Los Angeles upgraded from Kupp by adding Davante Adams. Other than that, there were no game-changing additions. The Rams are banking on their young defensive line to grow up.
When Sean McVay is your coach, anything is possible. I wouldn’t count the Rams out or as a regression candidate. They’ll always be a handful for the Niners.
Week 6: at Buccaneers - Sunday, October 12 - 10:00 a.m. PT
The Niners get extra rest to compensate for back-to-back road games, and this one is against Baker Mayfield and the Bucs. But it’ll be another early start on the east coast.
San Francisco has won the last four matchups in the series. Here, they’ll get one of the tougher matchups on their schedule in the first third of the season.
Week 7: vs. Falcons - Sunday, October 19th - 5:20 p.m. PT
The NFL sure is confident about the Falcons this season. Either that, or they want to show off former first-round pick Michael Penix. Regardless, the 49ers get a favorable matchup against a team that did nothing to help Penix out this offseason. The Falcons drafted two defensive players in the first round, but you could argue that neither of those players proved they were first-round talents. This is a game San Francisco needs to win if they are hoping to make the playoffs.
Week 8: at Texans - Sunday, October 26 - 10:00 a.m. PT
In the first of two road games, the 49ers find themselves against another playoff contender. DeMeco Ryans and one of the top defenses in the league will be a challenge. Not to mention, it’ll be one of the lone early-morning games this season.
But how will C.J. Stroud look in his third season? The 49ers are 5-1 all-time against the Texans and will look to keep their winning streak alive against Houston.
Week 9: at Giants - Sunday, November 2 - 10:00 a.m. PT
If you’re going to fly across the country for an early start, let it happen against a team projected to be one of the worst in the NFL. The Giants had an eyebrow-raising offseason. They signed Jameis Winston and Russell Wilson but then drafted Jaxson Dart. Good luck with that!
Week 10: vs. Rams - Sunday, November 9 - 1:25 p.m. PT
After initially meeting on primetime back in Week 5, the 49ers close out their season series with the Rams here in Week 10. Los Angeles has its bye week in Week 8 and then faces the New Orleans Saints at home before making the short trek to the Bay Area for Week 10.
The Niners need to win their division games. Getting one (or even both) from the Rams would help them push for the NFC West in 2025.
Week 11: at Cardinals - Sunday, November 16 - 1:05 p.m. PT
Back-to-back division games come in Weeks 10 and 11 as the 49ers travel to Arizona for a matchup with the Cardinals next. Arizona also has its bye in Week 8. They then face Dallas and Seattle on the road before returning home versus the 49ers.
San Francisco was also swept by Arizona in the season series in 2024. That came after four straight wins for the 49ers over the previous two years. Which trend will prevail in 2025?
Week 12: vs. Panthers - Monday, November 24, 5:15 p.m. PT
The third primetime game of the season is in Week 12 against Carolina, a team that was a bottom-seven team in the NFL in 2024.
The Panthers made some serious investments in the offseason but could still end up being one of the worst teams in the NFL in 2025. Coming off extra rest at Levi’s Stadium, this is a must-win for the 49ers in 2025.
Week 13: at Browns - Sunday, November 30, 10:00 a.m. PT
The Browns were the story of the NFL Draft for all of the wrong reasons. At this point in the season, who knows who will be their quarterback? Another trip across a couple of time zones with an early start. Still, that is no excuse to drop a game. Not to the lowly Browns.
Week 14: BYE
Week 15: vs. Titans - Sunday, December 14, 1:25 p.m. PT
By now, we’ll know whether No. 1 overall pick Cam Ward is legit or not. You can’t lose to a rookie quarterback at home. Not if you’re a serious contender.
Week 16: at Colts - Monday, December 22 - 5:15 p.m. PT
Will Anthony Richardson be the quarterback? Will it be Daniel Jones? Gus Bradley should know the Colts inside and out. It’ll be the second time in franchise history that the 49ers will face the Colts under the lights. It’s also the first time they’ll travel to Indy since Kyle Shanahan’s first season as a head coach.
Week 17: vs. Bears - Sunday, December 28 - 5:20 p.m. PT
The 49ers get another crack at Caleb Williams. Things went swimmingly for them last year, but Ben Johnson is now running the show. The 49ers will play primetime games in back-to-back weeks for the first time since the 2022 season when they did it in Weeks 10 and 11.
Week 18: vs. Seahawks - January 3/4
This game could be on a Saturday or Sunday, depending on how each season turns out for either team. The NFL is acting as if this game will have playoff ramifications. If the Niners are in a “win and you’re in” scenario, you can’t ask for a better situation for it to be at home against Sam Darnold.