🗓️ Week 1: Saints vs. Cardinals
Date: Sunday, Sept. 7, 2025
Time: Noon CT
Location: Caesars Superdome, New Orleans, LA
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Quick Take: The Cardinals lead the all-time regular season series 16-15…New Orleans won the last matchup in the Caesars Superdome 31-9, on Oct. 27, 2019…The Saints have an 8-4 regular season home record against the Cardinals, in addition to a 45-14 win in the 2009 NFC Wild Card Playoff…This is the third time the Saints will open up the season against the Cardinals, having lost the 1982 matchup at the Superdome and the 2015 opener in Glendale, Ariz…The Saints have won six consecutive season openers, the current longest such streak in the NFL…This will be the third straight campaign the Saints have opened their season in the Caesars Superdome…Saints S Tyrann Mathieu was originally a third-round pick of the Cardinals in the 2013 NFL Draft and spent his first five seasons in Arizona…Saints DE Cameron Jordan (Chandler HS) and QBs Spencer Rattler (Pinnacle HS in Phoenix) and Tyler Shough (Hamilton HS in Chandler) all grew up in the greater Phoenix area…Saints Edges Coach Jay Rodgers' brother, Richard, serves as assistant head coach & special teams coordinator for the Cardinals.
🗓️ Week 2: Saints vs. 49ers
Date: Sunday, Sept. 14, 2025
Time: Noon CT
Location: Caesars Superdome, New Orleans, LA
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Quick Take: This matchup will mark the first time since 2018 that the Saints have opened at home for their first two games…Old NFC West rivals for 31 seasons (1970-2001)…San Francisco leads the all-time regular season series 49-27-2…New Orleans Defensive Coordinator Brandon Staley served as San Francisco's assistant head coach/defense in 2024…Quarterbacks Coach Scott Tolzien served as a backup signal-caller in San Francisco for two seasons (2011-12)…CB Isaac Yiadom spent the 2024 season with the 49ers, where he appeared in all 17 contests with five starts, finishing with a career-high 44 tackles (career-best 36 solo), one interception, six pass breakups, a career-best two forced fumbles, one fumble recovery, two special teams stops and a recovery of a muffed punt.
🗓️ Week 3: Saints at Seahawks
Date: Sunday, Sept. 21, 2025
Time: 3:05 PM CT
Location: Lumen Field, Seattle, WA
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Quick Take: The Saints lead the all-time series matchup against Seattle 10-6, marking the club's best winning percentage (.625) versus an NFL opponent that it has played at least nine times…New Orleans has won the last four matchups against Seattle…The last Saints-Seahawks matchup at Lumen Field came during the 2021 regular season on Monday Night Football, where New Orleans claimed a 13-10 victory. RB Alvin Kamara led the team with ten receptions for 128 yards and a TD, only 11 receiving yards shy of his career-high…Seahawks Offensive Coordinator Klint Kubiak, Quarterbacks Coach Andrew Janocko, Offensive Line Coach John Benton and Run Game Coordinator/Senior Offensive Advisor Rick Dennison all served on New Orleans' offensive staff in 2024.
🗓️ Week 4: Saints at Bills
Date: Sunday, Sept. 28, 2025
Time: Noon CT
Location: Highmark Stadium, Orchard Park, NY
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Quick Take: With the Bills being New Orleans's first AFC opponent of the season, the Saints will visit Orchard Park for their sixth and final visit to Highmark Stadium, which will be replaced after the season…New Orleans has a 4-1 all-time road record against the Bills at Highmark Stadium, dating back to a 22-19 victory on Dec. 10, 1989…They have outscored Buffalo 141-69 in five road contests…This will be the first road matchup for the Saints against the Bills since Nov. 12, 2017, where New Orleans defeated Buffalo 47-10 behind the lethal rushing attack of Mark Ingram II (21 carries for 131 yards with 3 TDs) and Kamara (12 carries for 106 yards and one TD)…The Saints lead the all-time series 7-5, with the Bills winning the last matchup 31-6 in a Thanksgiving night matchup on November 21, 2021.