**JACKSONVILLE –** Senior writer John Oehser takes a week-by-week look at the [Jaguars’ 2025 schedule](https://www.jaguars.com/schedule/), which was announced Wednesday night by the NFL.
* **Carolina Panthers (5-12, 2024 third in NFC South) at EverBank Stadium, 1 p.m., FOX.**
* **Breakdown:** A little more than 30 years after the Jaguars and Panthers played in the 1995 Hall of Game in their inaugural season, they will open the '25 regular season in Jacksonville – marking the first time the Jaguars have opened the regular season at home since the 2020 COVID-19 season. This will mark the first game of the Jaguars' new era under Head Coach Liam Coen, General Manager James Gladstone and Executive Vice President of Football Operations Tony Boselli. This game on paper is critical for the Jaguars, with the six of the next seven games against teams that finished with winning records last season. The Panthers are entering their second season under Head Coach Dave Canales, taking a step forward after finishing with the league's worst record in 2023. The all-time series is tied 4-4 with the Jaguars leading 3-1 in Jacksonville. The Jaguars won the last meeting, 26-0, in Jacksonville in 2023.
* **Cincinnati Bengals (9-8, 2024 third in AFC North) at Paycor Stadium in Cincinnati, Ohio, 1 p.m., CBS.**
* **Breakdown:** This is the Jaguars' first road game of the '25 season, and the first of a difficult stretch before a Week 8 bye. It also could mark the second matchup between Jaguars quarterback Trevor Lawrence and Bengals quarterback Joe Burrow – the No. 1 overall selections in the 2021 and 2020 NFL Drafts, respectively. The Jaguars and Bengals have played twice since Lawrence's selection, but Burrow missed the 2023 meeting with an injury. The Bengals have missed the postseason the last two seasons under seventh-year head coach Zac Taylor, but they finished impressively last season and figure to enter the season as favorites to contend for the postseason in one of the NFL's best divisions. The Jaguars lead the series 13-12 and the Bengals are 8-5 against the Jaguars in Cincinnati. The Bengals won the last meeting in December 2023, 34-31, in overtime.
* **Houston Texans (10-7, 2024 first in AFC South) at EverBank Stadium, 1 p.m., CBS.**
* **Breakdown:** This is a key early-season AFC South game, with the Texans having won the last two division titles after the Jaguars won it in 2022. The Texans have won the division both of their seasons with DeMeco Ryans as head coach and C.J. Stroud at quarterback, and many observers project Houston to become the first team to win three consecutive AFC South titles since the Indianapolis Colts won five consecutive South titles from 2003-2007. The Jaguars and Texans split the season series in 2022 and 2023, with the Texans sweeping the series last season by winning 24-20 in Houston and 23-20 in Jacksonville. The Texans lead the all-time series 31-15, 15-8 in Jacksonville.
* **San Francisco 49ers (6-11, 2024 fourth in NFC West) at Levi's Stadium in Santa Clara, Calif., 4:05 p.m., FOX.**
* **Breakdown:** The 49ers sustained significant offseason personnel losses, but make no mistake: They're a front-line, well-coached organization under Head Coach Kyle Shanahan that hasn't had back-to-back losing seasons since 2017-2018. The Jaguars are 2-5 all-time against the 49ers, with the 49ers winning the last meeting – 34-3 in Jacksonville in 2023. The Jaguars are 0-2 all-time on the road against the 49ers.
* **Kansas City Chiefs (15-2, 2024 first in AFC West) at EverBank Stadium, 8:15 p.m., ESPN/ABC.**
* **Breakdown:** This is the Jaguars' lone prime-time game of the season – and their second game in two weeks against a 2024 division champion. The Chiefs are the NFL's model organization, never having a losing season in the last 12 seasons and winning the last nine AFC West titles. They have played in the last seven AFC Championship Games and five of the last six Super Bowls, winning three. Chiefs quarterback Patrick Mahomes is a two-time NFL Most Valuable Player (2018, 2022), a Pro Bowl selection from 2018-2023 and a three-time Super Bowl MVP (following the 2019, 2022 and 2023 seasons). The Chiefs lead the series 10-6 and the Jaguars are 2-3 against the Chiefs in Jacksonville. The Chiefs won the last meeting, 17-9, in Jacksonville in 2023.
* **Seattle Seahawks (10-7, 2024 second in NFC West) at EverBank Stadium, 1 p.m., FOX.**
* **Breakdown:** This marks the first of two consecutive NFC West opponents for the Jaguars leading into a Week 8 bye. The Seahawks are perennial contenders, with one losing season since 2011, and they transitioned last season from longtime Head Coach Pete Carroll with a 10-7 record in Mike Macdonald's first season as head coach. The Seahawks lead the series 6-3 and won the last meeting, 31-7 in Jacksonville in 2021. The Jaguars are 3-2 all-time against the Seahawks in Jacksonville.
* **Los Angeles Rams (10-7, 2024 first in NFC West) at Wembley Stadium in London, United Kingdom, 9:30 a.m., NFL Network.**
* **Breakdown:** This is an intriguing matchup, particularly from the Jaguars' perspective – with Jaguars' new leadership having strong ties to the Rams, one of the NFL's most-consistent organizations in recent seasons. Gladstone spent his first nine NFL seasons with the Rams and Coen spent 2018-2020 as an assistant with the Rams under Head Coach Sean McVay before spending 2022 as the Rams' offensive coordinator. The Rams are 5-1 all-time against the Jaguars and won the last meeting, 31-7, in Los Angeles in 2021. The Jaguars are 7-6 all-time in London, 5-5 at Wembley Stadium.