Week 3 sends the Steelers to New England to face new head coach Mike Vrabel. The Steelers have lost their past four trips to New England, with their last win coming in the 2008 season. Overall, they are 4-7 all-time on the road against the Patriots.
The Steelers and Vikings will play the NFL's first regular season game in Ireland in Week 4. It will mark the Steelers' first international game since they played in London in 2013, coincidentally also against the Vikings. Minnesota won that game, 34-27.
Following their AFC North games against the Browns and Bengals coming out of their bye week, the Steelers host the Packers in Week 8 in a Sunday night game Oct. 26.
The Steelers and Packers last met at Acrisure Stadium in 2023, with the Steelers winning, 23-19. The Steelers have won their past six meetings with Green Bay in Pittsburgh and are 9-7 overall at home against the Packers.
In Week 9, the Colts come to Pittsburgh on Nov. 2 to kick off the second half of the schedule. The Steelers are 17-2 in their history against the Colts in Pittsburgh and haven't lost a home game to Indianapolis since 2008, winning the past four meetings at Acrisure Stadium.
Week 10 sends the Steelers to Los Angeles to face the Chargers in another Sunday night contest. The Steelers have faced the Chargers 16 times on the road, winning nine of those games. But the Chargers won the last meeting, beating the Steelers, 41-37, in a shootout in 2021.
The Steelers host the Bengals on Nov. 16 for a 1 p.m. game in their second meeting with Cincinnati. The Steelers have won 15 of their past 20 meetings with Cincinnati, though the two teams split their games in 2024, with Pittsburgh winning in Cincinnati and the Bengals returning the favor in a Week 18 game.
On Nov. 23, the Steelers travel to Chicago, a place where they haven't had a lot of success. The Steelers are just 1-12 in their history in Chicago, with the only win coming in overtime, 37-34, in 1995. They have lost all three games they have played in Chicago since, including 23-17 in 2017, their last trip to Soldier Field.
The Steelers return home in Week 13 to host the Bills Nov. 30. Though the two franchises have met five times in the past seven seasons, including once in the playoffs, this will mark Buffalo's first trip to Pittsburgh since the 2019 season, a game the Bills won, 17-10.
Overall, the Steelers are 10-3 against Buffalo in Pittsburgh, winning six of the past seven meetings dating back to a 1993 playoff game.