The Buffalo Bills are the only NFL team to be favored in all of their games in the early betting lines for the upcoming season.
The tightest lines for Buffalo ahead of the 2025-2026 season are against AFC rivals the Baltimore Ravens and Kansas City Chiefs and against the NFC’s Philadelphia Eagles, the defending Super Bowl champions, though all three are home games. The Bills and MVP-winning quarterback Josh Allen are favored by 1.5 points against the Ravens and Eagles and by 2.5 points against the Chiefs on DraftKings, according to CBS Sports. They are most heavily favored in a Sept. 28 home game against the New Orleans Saints, with a line of 12.5 points.
The lines mean that bets made now on the Bills to cover the spread will win if the team beats the Ravens or Eagles by at least two points, the Chiefs by at least three points and the Saints by at least 13 points. The Bills are also heavily favored against all three of their AFC East division rivals, each of whom they face twice.
Buffalo is favored by 8.5 points against the New York Jets on the road on Sept. 14 and 9.5 points against them at home on Jan. 4. They are favored by 8.5 points against both the Miami Dolphins and New England Patriots at home on Sept. 18 and Oct. 5, respectively, and 5.5 points on the road against the two teams on Nov. 9 and Dec. 14, respectively, according to CBS Sports.
Using the projected win totals from oddsmakers in Las Vegas, the Buffalo Bills have the fifth-easiest schedule for the season, according to Sharp Football Analysis. Caesars Sportsbook is favoring the team to have the most wins in the NFL this season, according to the Las Vegas Review-Journal.
Favorites did well during the 2024-2025 season, winning 195 games and losing 77, the best record for favored teams since 2005, according to ESPN. Buffalo’s projected win and loss total is well below a perfect 17 games; BetMGM has the team’s over/under at 11.5 wins, according to The Athletic, while Caesars Sportsbook has it at 12.5 wins, according to the Las Vegas Review-Journal. The last team to enter the postseason with a perfect regular season record was the 2007 New England Patriots, and the only team to win a Super Bowl as part of an undefeated season was the 1972 Miami Dolphins.
The Bills, who have never won a Super Bowl and who have not been to one since their back-to-back-to-back-to-back Super Bowl losses in the early 1990s, currently have the third-best odds to win it all on BetMGM at +750. A $100 bet with those odds would net a player $750 in winnings ($850 total when including the initial wager).