Don't blow off Week 2.The sports world is making the transition from the first full opening weekend of the college football season to buzzing about the NFL. But now is when we're in the thick of things on the college side with an interesting Week 2.There might not be the monster matchups, but there will be big things happening. Below are the Expert Picks for Arizona State at Miss State, Baylor at SMU, Boston College at Michigan State, FIU at Penn State, Illinois at Duke, Iowa at Iowa State, James Madison at Louisville, Kansas at Missouri, Louisiana Tech at LSU, Michigan at Oklahoma, Northern Illinois at Maryland, Oklahoma State at Oregon, Ole Miss at Kentucky, San Jose State at Texas, USF at Florida, Georgia Southern at USC, and at the bottom are the results so far.
Week 2 College Football Expert Picks and Predictions
James Madison at Louisville
Game Time: 7:00 PM ETTV: ESPN2Consensus Line: Louisville -14- Game Preview & Prediction COMINGBig Game Ben: Louisville*E: Louisville*Nathan Erbach: LouisvillePete Fiutak: LouisvilleJohn Kennedy: LouisvilleJackson Langendorf: LouisvilleAndrew Margolick: Louisville*Jake Margolick: Louisville*Doug Millen: LouisvilleJohnny Rosenstein: Louisville*Joshua Schulman: LouisvilleNick Shepkowski: Louisville*Clucko the Chicken: James MadisonCONSENSUS PICK: Louisville*
Northern Illinois at Maryland
Game Time: 7:30 PM ETTV: BTNConsensus Line: Maryland -17.5- Game Preview & PredictionBig Game Ben: MarylandE: MarylandNathan Erbach: Maryland*Pete Fiutak: MarylandJohn Kennedy: MarylandJackson Langendorf: Maryland*Andrew Margolick: MarylandJake Margolick: MarylandDoug Millen: Maryland*Johnny Rosenstein: Maryland*Joshua Schulman: Maryland*Nick Shepkowski: Maryland*Clucko the Chicken: MarylandCONSENSUS PICK: Maryland
San Jose State at Texas
Game Time: 12:00 PM ETTV:Consensus Line: Texas -36.5- Game Preview & Prediction COMINGBig Game Ben: Texas*E: TexasNathan Erbach: TexasPete Fiutak: TexasJohn Kennedy: TexasJackson Langendorf: TexasAndrew Margolick: Texas*Jake Margolick: TexasDoug Millen: TexasJohnny Rosenstein: Texas*Joshua Schulman: TexasNick Shepkowski: TexasClucko the Chicken: TexasCONSENSUS PICK: Texas
FIU at Penn State
Game Time: 12:00 PM ETTV: BTNConsensus Line: Penn State -41.5- Game Preview & PredictionBig Game Ben: Penn State*E: Penn StateNathan Erbach: Penn State*Pete Fiutak: Penn StateJohn Kennedy: Penn StateJackson Langendorf: Penn State*Andrew Margolick: Penn StateJake Margolick: Penn State*Doug Millen: Penn StateJohnny Rosenstein: Penn State*Joshua Schulman: Penn State*Nick Shepkowski: Penn StateClucko the Chicken: FIUCONSENSUS PICK: Penn State*
Illinois at Duke
Game Time: 12:00 PM ETTV: ESPNConsensus Line: Illinois -3- Game Preview & PredictionBig Game Ben: IllinoisE: IllinoisNathan Erbach: IllinoisPete Fiutak: IllinoisJohn Kennedy: IllinoisJackson Langendorf: IllinoisAndrew Margolick: IllinoisJake Margolick: DukeDoug Millen: IllinoisJohnny Rosenstein: DukeJoshua Schulman: DukeNick Shepkowski: DukeClucko the Chicken: DukeCONSENSUS PICK: Illinois
Aug 30, 2025; Dallas, Texas, USA; Southern Methodist Mustangs wide receiver Jalen Cooper (10) scores a touchdown against the East Texas A&M Lions during the second half at Gerald J. Ford Stadium. © Jerome Miron-Imagn Images
Baylor at SMU
Game Time: 12:00 PM ETTV: CW NetworkConsensus Line: SMU -3- Game Preview & Prediction COMINGBig Game Ben: SMUE: SMUNathan Erbach: BaylorPete Fiutak: SMUJohn Kennedy: SMUJackson Langendorf: SMUAndrew Margolick: BaylorJake Margolick: BaylorDoug Millen: BaylorJohnny Rosenstein: SMUJoshua Schulman: SMUNick Shepkowski: SMU*Clucko the Chicken: SMUCONSENSUS PICK: SMU
Iowa at Iowa State
Game Time: 12:00 PM ETTV: FOXConsensus Line: Iowa State -3- Game Preview & PredictionBig Game Ben: Iowa StateE: IowaNathan Erbach: IowaPete Fiutak: IowaJohn Kennedy: Iowa StateJackson Langendorf: IowaAndrew Margolick: Iowa StateJake Margolick: Iowa StateDoug Millen: Iowa StateJohnny Rosenstein: Iowa StateJoshua Schulman: Iowa StateNick Shepkowski: Iowa State*Clucko the Chicken: IowaCONSENSUS PICK: Iowa State
Oklahoma State at Oregon
Game Time: 3:30 PM ETTV: CBSConsensus Line: Oregon -28.5- Game Preview & PredictionBig Game Ben: Oregon*E: Oregon*Nathan Erbach: Oregon*Pete Fiutak: Oregon*John Kennedy: Oregon*Jackson Langendorf: OregonAndrew Margolick: OregonJake Margolick: Oregon*Doug Millen: OregonJohnny Rosenstein: OregonJoshua Schulman: Oregon*Nick Shepkowski: OregonClucko the Chicken: Oklahoma StateCONSENSUS PICK: Oregon*
Ole Miss at Kentucky
Game Time: 3:30 PM ETTV: ABCConsensus Line: Kentucky -10- Game Preview & Prediction COMINGBig Game Ben: Ole Miss*E: KentuckyNathan Erbach: Ole MissPete Fiutak: Ole Miss*John Kennedy: Ole MissJackson Langendorf: Ole MissAndrew Margolick: Ole MissJake Margolick: Ole Miss*Doug Millen: Ole MissJohnny Rosenstein: Ole MissJoshua Schulman: Ole MissNick Shepkowski: Ole MissClucko the Chicken: KentuckyCONSENSUS PICK: Ole Miss
Kansas at Missouri
Game Time: 3:30 PM ETTV: ESPN2Consensus Line: Missouri -6.5- Game Preview & Prediction COMINGBig Game Ben: KansasE: KansasNathan Erbach: KansasPete Fiutak: Missouri*John Kennedy: MissouriJackson Langendorf: KansasAndrew Margolick: Missouri*Jake Margolick: KansasDoug Millen: MissouriJohnny Rosenstein: Missouri*Joshua Schulman: KansasNick Shepkowski: MissouriClucko the Chicken: MissouriCONSENSUS PICK: Missouri*
USF at Florida
Game Time: 4:15 PM ETTV: SEC NetworkConsensus Line: Florida -17.5- Game Preview & Prediction COMINGBig Game Ben: Florida*E: FloridaNathan Erbach: FloridaPete Fiutak: FloridaJohn Kennedy: Florida *Jackson Langendorf: Florida*Andrew Margolick: FloridaJake Margolick: Florida*Doug Millen: FloridaJohnny Rosenstein: Florida*Joshua Schulman: Florida*Nick Shepkowski: Florida*Clucko the Chicken: USFCONSENSUS PICK: Florida*
Louisiana Tech at LSU
Game Time: 7:30 PM ETTV: ESPN+Consensus Line: LSU -37.5- Game Preview & Prediction COMINGBig Game Ben: LSUE: LSU*Nathan Erbach: LSU*Pete Fiutak: LSUJohn Kennedy: LSU *Jackson Langendorf: LSUAndrew Margolick: LSU*Jake Margolick: LSUDoug Millen: LSU*Johnny Rosenstein: LSU*Joshua Schulman: LSU*Nick Shepkowski: LSU*Clucko the Chicken: LSUCONSENSUS PICK: LSU*
Mississippi State Bulldogs safety Brylan Lanier (3) reacts after a turnover against the Southern Miss Golden Eagles during the fourth quarter at M.M. Roberts Stadium in Hattiesburg, Miss., on Aug. 30, 2025. © Matt Bush/Special to Clarion Ledger / USA TODAY NETWORK via Imagn Images
Arizona State at Miss State
Game Time: 7:30 PM ETTV: ESPN2Consensus Line: Arizona State -7- Game Preview & Prediction COMINGBig Game Ben: Arizona StateE: Arizona StateNathan Erbach: Arizona StatePete Fiutak: Miss StateJohn Kennedy: Arizona StateJackson Langendorf: Arizona StateAndrew Margolick: Miss StateJake Margolick: Arizona State*Doug Millen: Miss StateJohnny Rosenstein: Arizona State*Joshua Schulman: Arizona State*Nick Shepkowski: Arizona StateClucko the Chicken: Miss StateCONSENSUS PICK: Arizona State
Michigan at Oklahoma
Game Time: 7:30 PM ETTV: ABCConsensus Line: Oklahoma -5.5- Game Preview & PredictionBig Game Ben: MichiganE: MichiganNathan Erbach: OklahomaPete Fiutak: OklahomaJohn Kennedy: OklahomaJackson Langendorf: MichiganAndrew Margolick: OklahomaJake Margolick: MichiganDoug Millen: MichiganJohnny Rosenstein: Oklahoma*Joshua Schulman: OklahomaNick Shepkowski: Oklahoma*Clucko the Chicken: OklahomaCONSENSUS PICK: Oklahoma*
Georgia Southern at USC
Game Time: 7:30 PM ETTV: FS1Consensus Line: USC -28.5- Game Preview & Prediction COMINGBig Game Ben: USCE: USCNathan Erbach: USCPete Fiutak: USCJohn Kennedy: USCJackson Langendorf: USCAndrew Margolick: USCJake Margolick: USCDoug Millen: USCJohnny Rosenstein: USCJoshua Schulman: USCNick Shepkowski: USCClucko the Chicken: Georgia SouthernCONSENSUS PICK: USC
Boston College at Michigan State
Game Time: 7:30 PM ETTV: NBC/PeacockConsensus Line: Michigan State -3.5- Game Preview & Prediction COMINGBig Game Ben: Boston CollegeE: Michigan StateNathan Erbach: Boston CollegePete Fiutak: Michigan StateJohn Kennedy: Boston CollegeJackson Langendorf: Boston CollegeAndrew Margolick: Boston CollegeJake Margolick: Michigan StateDoug Millen: Michigan StateJohnny Rosenstein: Michigan State*Joshua Schulman: Michigan StateNick Shepkowski: Boston CollegeClucko the Chicken: Boston CollegeCONSENSUS PICK: Boston College Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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