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Christian McCaffery injury rocks San Francisco 49ers

By JACK BEZANTS, US DEPUTY SPORTS EDITOR

Published: 20:12 EDT, 4 September 2025 | Updated: 20:12 EDT, 4 September 2025

The San Francisco 49ers have added Christian McCaffrey to their injury report with a calf injury in what is a major scare before their first game of the season on Sunday.

The running back, 29, missed most of last season with Achilles tendonitis followed by a knee ligament tear.

He practiced fully on Wednesday, so Thursday's development is a huge concern before Sunday's game on the road against Seattle Seahawks.

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