United completed the signing of Senne Lammens from Royal Antwerp on deadline day of the summer window and the Belgian goalkeeper would love to make his debut in the derby clash. It could prove to be the battle of the two goalkeepers at the Etihad Stadium, with Gianluigi Donnarumma eager to start for City after he signed from Paris Saint-Germain.
United actually head into the clash ahead of City in the Premier League table and both sides will hope for three points to kickstart their respective campaigns and show a strong signal of intent.
With all that in mind, here is a look at how we think United should line up next weekend:
It would be a huge call to start Lammens against City and Onana could be given the chance to prove himself.
1. GK - Andre Onana
It would be a huge call to start Lammens against City and Onana could be given the chance to prove himself. | AFP via Getty Images
Yoro is certain to start in the backline after an impressive start to the new season.
2. CB - Leny Yoro
Yoro is certain to start in the backline after an impressive start to the new season. | Getty Images
De Ligt is currently the first-choice option for Ruben Amorim in central defence.
3. CB - Matthijs De Ligt
De Ligt is currently the first-choice option for Ruben Amorim in central defence. | Manchester United via Getty Images
Lisandro Martinez aims to return to action this month but Shaw is most likely to start the derby.
4. CB - Luke Shaw
Lisandro Martinez aims to return to action this month but Shaw is most likely to start the derby. | Manchester United via Getty Images