What we're hearing on the Bills: An issue for Buffalo in Week 1 was limiting the running game after giving up a league-high 238 rushing yards. The Jets put up the fourth-most rushing yards in Week 1 (182 yards) and slowing them down will be more difficult with DT Ed Oliver, who is coming off a big game, dealing with an ankle injury. "We need to get those things corrected, and we will," defensive coordinator Bobby Babich said when asked about the run defense. "We'll be very intentional this week about getting those things." -- Alaina Getzenberg
What we're hearing on the Jets: The Jets always have scoring problems against the Bills -- they've been held under 23 points in the past 12 meetings -- but there's a renewed confidence on offense after a 32-point showing in Week 1. The running game is a big part of "our DNA," offensive coordinator Tanner Engstrand said. Result: 11 explosive plays against the Steelers, three more than their weekly goal. -- Rich Cimini
Stat to know: Josh Allen has 18 career turnovers against the Jets, the most by any quarterback against a single opponent since he entered the league in 2018. -- ESPN Research
Bold prediction: Jets CB Brandon Stephens will be targeted at least nine times as the nearest defender, tying the high-water mark for any defender in Week 1. Stephens is coming off a rough first game as a Jet in which he gave up 75 yards on seven targets and is also coming off a shaky final season in Baltimore. With Sauce Gardner playing opposite him, expect Buffalo to target Stephens. -- Walder
Fantasy nugget: Breece Hall faces a Bills defense that gave up 29.2 fantasy points to Derrick Henry last week and has struggled against RBs dating to last season. Hall is coming off a performance in which he stockpiled 21 touches and 16.5 fantasy points. He has averaged 15.5 fantasy points per game against the Bills in his career. See Week 2 rankings. -- Moody
Betting nugget: The Bills have covered three straight meetings against the Jets. Read more. -- ESPN Research
Maldonado's pick: Bills 22, Jets 21
Moody's pick: Bills 36, Jets 27
Walder's pick: Bills 27, Jets 16
FPI prediction: BUF, 65.5% (by an average of 6.3 points)