The play followed a takeaway by Minnesota's defense that resulted from Eric Wilson forcing a fumble after a 20-yard reception by Atlanta's Drake London. Theo Jackson recovered the football and returned it 10 yards to set Minnesota up at its 32 with 1:28 remaining in the first quarter.
Fitzgerald accomplished the 500-catch milestone in 2009 with the Arizona Cardinals.
Cowboys receiver CeeDee Lamb reached 500 catches in Week 1 at 26 years and 149 days of age and is now the third youngest.
Minnesota's 2025 home opener is Jefferson's 79th regular-season game.
Michael Thomas is the only NFL player to reach 500 receptions in fewer games, accomplishing the feat in his 69th game.