Bryan teed up Vitaly Janelt and future Red Christian Eriksen in a 4-1 victory in 2022 and made it on to the scoresheet himself as they triumphed 2-0 the following season.
Mbeumo grabbed another goal and assist as this scoreline was repeated six months later and, although Brentford were beaten 2-1 at the Bridge last term, the Cameroon international again netted in SW6.
According to Opta, this is the joint-most goal involvements a player has managed against a single opponent with none coming at home in the Premier League, but, with United hosting Chelsea on Saturday, let's hope this changes soon!
Here are four more fast facts to know ahead of our meeting with Enzo Maresca's side...