City's league phase also includes matches against Monaco (away), Villarreal (away), Borussia Dortmund (home), Leverkusen (home) and Bodo/Glimt (away). The top eight clubs from this phase will advance directly to the round of 16, while those finishing ninth to 24th will compete in the play-off round - a stage City are keen to bypass.
However, their immediate focus is on their encounter with Napoli, now under the management of former Chelsea, Tottenham and Italy boss Antonio Conte. Here's all you need to know about the, including kick-off time, TV channel and streaming information...
What time does Man City vs Napoli start?
The match is set to commence at 8pm on Thursday, September 18
What channel is Man City vs Napoli on?
The match will be aired live on TNT Sports 2 and the Discovery+ app, with coverage beginning an hour prior to kick-off at 7pm.
The evening's other fixtures, including Newcastle vs Barcelona, will also be aired across the TNT Sports network and Discovery+. If you're not a subscriber, Discovery+, which provides access to all TNT Sports channels, is priced at £30.99 per month with no long-term commitment.
What's the Man City vs Napoli team news?
The most intriguing part of the team news will be whether City legend De Bruyne plays against his former club. The Belgian icon, 34, is expected to start the match, having settled well following his free agent transfer to Napoli, who have made an excellent start to the season, topping Serie A with maximum points from three games.
For City, with Sunday's showdown against Arsenal on the horizon, Guardiola has been pondering whether to field John Stones after the defender missed the derby with a minor injury. Mateo Kovacic, Rayan Cherki, Rayan Ait-Nouri and Omar Marmoush remain sidelined, while Guardiola may opt to rest Rodri, considering his recent lengthy injury layoff and the Arsenal game.