Ethan Pinnock and Keane Lewis-Potter are the pair to make way, with both players named among the substitutes.
Fábio Carvalho and Reiss Nelson are not in the matchday squad.
> 🐝 Your Bees to take on Manchester United [pic.twitter.com/mNUI9oxNXk](https://t.co/mNUI9oxNXk)
>
> — Brentford FC (@BrentfordFC) [September 27, 2025](https://twitter.com/BrentfordFC/status/1971881356960653669?ref_src=twsrc%5Etfw)
**Brentford (4-3-3):** Kelleher; Kayode, Collins, van den Berg, Hickey; Henderson, Yarmoliuk, Damsgaard; Ouattara, Thiago, Schade
**Subs:** Valdimarsson, Henry, Pinnock, Jensen, Onyeka, Milambo, Ajer, Lewis-Potter, Janelt
**Manchester United (3-4-2-1):** Bayındır; de Ligt, Maguire, Shaw; Dalot, Ugarte, Fernandes, Dorgu; Mbeumo, Cunha; Šeško
**Subs:** Heaton, Lammens, Fredricson, Heaven, Leon, Yoro, Mainoo, Mount, Zirkzee