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Week 5 of the 2025 NFL season begins with the San Francisco 49ers making the trip to Inglewood, California, to take on the Los Angeles Rams for "Thursday Night Football."
Both teams enter the game 3-1, but San Francisco is notably beat up. Starting quarterback Brock Purdy is dealing with a toe injury and was expected to be listed as questionable for the contest. Instead, when the final injury report came out on Wednesday, Purdy was ruled out, paving the way for Mac Jones to start another game for the 49ers.
San Francisco's injury report didn't stop there as Ricky Pearsall and Jauan Jennings were also ruled out for the game, leaving the Niners' offense depleted.
Los Angeles comes into this game off a win over the Indianapolis Colts. Wide receiver Puka Nacua continued his hot start to the season and finished with 170 yards and a touchdown on 13 receptions. Veteran quarterback Matthew Stafford is already up to 1,114 passing yards with eight touchdowns and two interceptions in four games.
Linebacker Byron Young, who leads the Rams and is tied for the overall league lead with five sacks, will look to introduce himself to the San Francisco backfield early and often on Thursday night.
The Sporting News has you covered with LIVE updates, results and highlights from the 49ers-Rams Week 5 "Thursday Night Football" game.
STREAM: Watch 49ers vs. Rams live with Amazon Prime
49ers vs. Rams score
49ers vs. Rams live updates, highlights from Thursday Night Football
4:21 p.m.: Mac Jones has arrived ahead of Thursday Night Football. Jones backed up Brock Purdy on Sunday against the Jacksonville Jaguars, but Purdy was ruled out for tonight's contest earlier in the week.
#49ers QB Mac Jones arrives for #TNFonPrime pic.twitter.com/F2LFOu1hxY
— Clayton Holloway (@HollowayNFLN) October 2, 2025
Jones has 563 yards, four touchdowns and an interception in two starts with San Francisco. The 49ers are 2-0 with Jones as a starter.
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Where to watch 49ers vs. Rams tonight
49ers vs Rams start time
Date: Thursday, October 2
Start time: 8:15 p.m. ET
"Thursday Night Football" between the 49ers and Rams will kick off at 8:15 p.m. ET. The game will be held at SoFi Stadium in Inglewood, California, which means it will begin at 5:15 p.m. PT local time.
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What channel is 49ers vs. Rams on today?
Date: Thursday, October 2
TV Channel: None, except local markets
Live stream: Amazon Prime
The Week 5 matchup between the 49ers and Rams will primarily be carried on Amazon Prime. It will only air on TV in local San Francisco and Los Angeles markets, and will be on a Fox affiliate in those areas.
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49ers schedule 2025
Week Date Opponent Kickoff time (ET) TV channel
1 Sunday, Sept. 7 at Seahawks 4:05 p.m. Fox
2 Sunday, Sept. 14 at Saints 1 p.m. Fox
3 Sunday, Sept. 21 vs. Cardinals 4:25 p.m. Fox
4 Sunday, Sept. 28 vs. Jaguars 4:05 p.m. Fox
5 Thursday, Oct. 2 at Rams 8:15 p.m. Prime Video
6 Sunday, Oct. 12 at Buccaneers 4:25 p.m. CBS
7 Sunday, Oct. 19 vs. Falcons 8:30 p.m. NBC
8 Sunday, Oct. 26 at Texans 1 p.m. Fox
9 Sunday, Nov. 2 at Giants 1 p.m. CBS
10 Sunday, Nov. 9 vs. Rams 4:25 p.m. Fox
11 Sunday, Nov. 16 at Cardinals 4:05 p.m. Fox
12 Monday, Nov. 24 vs. Panthers 8:15 p.m. ESPN
13 Sunday, Nov. 30 at Browns 1 p.m. CBS
14 BYE — — —
15 Sunday, Dec. 14 vs. Titans 4:25 p.m. Fox
16 Monday, Dec. 22 at Colts 8:15 p.m. ESPN
17 Sunday, Dec. 28 vs. Bears 8:20 p.m. NBC
18 TBD vs. Seahawks TBD TBD
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Rams schedule 2025
Week Date Opponent Kickoff Time TV Channel
1 Sunday, Sept. 7 vs. Texans 4:25 p.m. CBS
2 Sunday, Sept. 14 at Titans 1 p.m. CBS
3 Sunday, Sept. 21 at Eagles 1 p.m. Fox
4 Sunday, Sept. 28 vs. Colts 4:05 p.m. Fox
5 Thursday, Oct. 2 vs. 49ers (TNF) 8:15 p.m. Prime Video
6 Sunday, Oct. 12 at Ravens 1 p.m. Fox
7 Sunday, Oct. 19 vs. Jaguars (London) 9:30 a.m. NFL Network
8 BYE — — —
9 Sunday, Nov. 2 vs. Saints 4:05 p.m. Fox
10 Sunday, Nov. 9 at 49ers 4:25 p.m. Fox
11 Sunday, Nov. 16 vs. Seahawks 4:05 p.m. Fox
12 Sunday, Nov. 23 vs. Buccaneers (SNF) 8:20 p.m. NBC
13 Sunday, Nov. 30 at Panthers 1 p.m. Fox
14 Sunday, Dec. 7 at Cardfinals 4:25 p.m. Fox
15 Sunday, Dec. 14 vs. Lions 4:25 p.m. Fox
16 Thursday, Dec. 18 at Seahawks (TNF) 8:15 p.m. Prime Video
17 Monday, Dec. 29 at Falcons (MNF) 8:15 p.m. ESPN
18 TBD vs. Cardinals TBD TBD