NOW PLAYING video We've got a tie! Stafford's third TD pass of night makes it a 20-20 game on 'TNF' Los Angeles Rams quarterback Matthew Stafford connects with Kyren Williams again for an 8-yard touchdown.
NOW PLAYING video Davante Adams' crossing-route reception gets Rams down to 49ers' 8-yard line Los Angeles Rams wide receiver Davante Adams captures a 24-yard first down off a ball from quarterback Matthew Stafford.
NOW PLAYING video Stafford has 'Vante vision with a 26-yard pass to Adams Los Angeles Rams quarterback Matthew Stafford slings a 26-yard dot to wide receiver Davante Adams.
NOW PLAYING video Puka Nacua reaches 50-catch mark for the 2025 season in Rams' fifth game Los Angeles Rams wide receiver Puka Nacua catches a 9-yard ball from quarterback Matthew Stafford to mark his 50th reception of 2025.
video Nate Landman's speedy TFL vs. McCaffrey forces 49ers into punt formation Los Angeles Rams linebacker Nate Landman stuffs San Francisco 49ers running back Christian McCaffery to force a fourth down.
video Stafford's TD pass to Nacua trims 49ers' lead to 20-12 on 'TNF' Los Angeles Rams quarterback Matthew Stafford gets rid of the ball quickly for a 1-yard touchdown from wide receiver Puka Nacua.
video Puka Nacua's fifth catch of 'TNF' gets Rams into red zone in third quarter Los Angeles Rams wide receiver Puka Nacua pushes for extra yardage on 16-yard catch and run from quarterback Matthew Stafford.
video Stafford's 35-yard deep ball pinpoints Tutu Atwell amid tight coverage Los Angeles Rams quarterback Matthew Stafford uncorks a 35-yard ball to wide receiver Tutu Atwell who rings it in under pressure.
video Eddy Piñeiro's chips in 20-yard FG to extend Niners lead 20-7 San Francisco 49ers kicker Eddy Piñeiro's puts up a 20-yard field goal.
video Mac Jones' 19-yard sideline strike to Bourne gets 49ers into Rams territory San Francisco 49ers wide receiver Kendrick Bourne toe drags for a 19-yard reception from quarterback Mac Jones.
video Karty's 53-yard missed kick goes wide right Los Angeles Rams kicker Joshua Karty misses a 53-yard field goal.
video Davis Allen reels in bobbled 20-yard catch for first down Los Angeles Rams tight end Davis Allen corrals a 20-yard pass from quarterback Matthew Stafford.
video Eddy Piñeiro's 37-yard FG boosts 49ers' lead to 17-7 over Rams at halftime San Francisco 49ers kicker Eddy Pineiro knocks in a 37-yard field goal.
video Kyren Williams' high-stepping TD caps Rams' 85-yard drive vs. 49ers Los Angeles Rams running back Kyren Williams prances into the endzone off a 14-yard touchdown pass from quarterback Matthew Stafford.
video Stafford's 22-yard laser pinpoints Whittington in 49ers' territory Los Angeles Rams quarterback Matthew Stafford finds wide receiver Jordan Whittington open downfield for a 22-yard gain.
video Terrance Ferguson's first NFL catch goes for 21-yard gain vs. 49ers Los Angeles Rams rookie tight end Terrance Ferguson makes a contested 21-yard grab from quarterback Matthew Stafford for his first NFL catch.
video Trevis Gipson snags a 49ers takeaway thanks to Rams' botched handoff San Francisco 49ers linebacker Trevis Gipson recovers bobble from Los Angeles Rams running back Blake Corum for a turnover.
video Mac Jones' second TD pass of first half pinpoints McCaffrey inside the end zone San Francisco 49ers quarterback Mac Jones connects with running back Christian McCaffery for a 1-yard touchdown to extend lead to 14-0 against the Los Angeles Rams.
video Mac Jones' 18-yard loft to Demarcus Robinson comes on back-shoulder delivery San Francisco 49ers wide receiver Demarcus Robinson catches an 18-yard pass from quarterback Mac Jones to enter the red zone against former team Los Angeles Rams.
video Trick-play alert! 49ers' flea-flicker-style call yields 8-yard gain for CMC San Francisco 49ers quarterback Mac Jones tosses the ball to wide receiver Kendrick Bourne who flicks it back to Jones who hits running back Christian McCaffery for an 8-yard gain.
video Bryce Huff's sneak-attack-sack sends Stafford back 11 yards San Francisco 49ers defensive end Bryce Huff bull rushes Los Angeles Rams quarterback Matthew Stafford for an 11-yard sack.
video Jake Tonges' third TD catch of 2025 opens scoring in 49ers-Rams on 'TNF' San Francisco 49ers tight end Jake Tonges is wide open for a 6-yard touchdown pass from quarterback Mac Jones.
video Track Kendrick Bourne's 35-yard reception with 'TNF' Prime Vision San Francisco 49ers wide receiver Kendrick Bourne catches a 35-yard reception from quarterback Mac Jones against the Los Angeles Rams.
video Kendrick Bourne's first catch of game goes for 35-yard gain via YAC skills down sideline San Francisco 49ers quarterback Mac Jones hits wide receiver Kendrick Bourne for a 35-yard gain.
video CMC's first reception of 'TNF' ends in 15-yard dicing of Rams defense San Francisco 49ers running back Christian McCaffery slips through a tackle after 15-yard catch and run from quarterback Mac Jones.