TEMPE — “Same stuff, different day.”
There’s not much Arizona Cardinals quarterback Jacoby Brissett hasn’t seen in his 10-year career that spans seven stops with six different franchises.
That includes spot starting, which could very well happen in Week 6 against the Indianapolis Colts.
While quarterback Kyler Murray turned in a limited day of practice on Friday, the franchise signal caller missed the two days prior with a foot injury picked up in last week’s loss to the Tennessee Titans.
And it was Brissett, not Murray, largely leading drills during the open portion of Friday’s work, getting extended reps in with starters Marvin Harrison Jr. and Trey McBride, among others.
Cardinals QB Jacoby Brissett working with Trey McBride and Marvin Harrison Jr. pic.twitter.com/XjCE2ignc4
— Tyler Drake (@Tdrake4sports) October 10, 2025
Brissett then held court with reporters, something Murray typically does on a healthy week, albeit on a Wednesday.
Maybe it’s the ultimate display of gamesmanship. Maybe it’s not.
Either way, Brissett is prepared for the opportunity.
Cardinals QB Jacoby Brissett has the utmost confidence in himself and plenty of knowledge of the system if he’s called upon to start vs. the Colts. pic.twitter.com/0zeZNFXEk6
— Tyler Drake (@Tdrake4sports) October 10, 2025
“I’ve been in this offense before with (offensive coordinator Drew Petzing). It was one of the reasons why I chose this place,” Brissett said Friday. “I have the utmost confidence in myself and the offense and the guys that we have.”
If Murray in fact can’t go — he’s currently listed as questionable — Brissett at the very least brings experience, whether it be working with Petzing back in Cleveland or elsewhere.
His 53 starts across 89 games played say all you need to know.
Petzing, who was Brissett’s quarterbacks coach in Cleveland, got a good look of what a Brissett-led offense can bring to the table, too.
In 11 starts (16 games played) for the 2022 Browns, Brissett completed 64% of his throws for 2,608 yards and 12 touchdowns to six interceptions.
The 6-foot-4 signal caller added another 243 yards and two scores on 49 carries.
Fast forward to 2025, and Brissett has set himself up to take the reins yet again if called upon.
A big part of that has centered around putting the extra time after practice with Harrison and others.
They may not have the game reps banked, but there’s still a connection formed.
“I have full trust in Jacoby,” Harrison said Wednesday. “I think the biggest thing is he’s been such a good leader and mentor for me since he’s got here. I’m excited to see if he gets the opportunity.”
That could pay dividends this week, especially when looking at how productive then-No. 1 option Amari Cooper was for the Browns with Brissett largely running the show.
But no matter if it’s Murray or Brissett, the Cardinals are up against it this week with tough road battle against the Colts.
The defense has been among the stingiest in 2025, ranking in the top in points allowed (17.8 per game) and turnovers (eight).