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NFL Picks Against the Spread: Week 6 Games

Before the sixth Sunday of the 2025 regular season kicks off, let’s have some fun by taking a look at the lines for the NFL Week 6 games.

My overall record is 35-42-1. Trying to get over .500. The BGN Community is better at 37-40-1.

Here are suggestions when trying to beat the odds.

**CLEVELAND BROWNS at PITTSBURGH STEELERS (-6.5):** The Steelers are well-rested coming off the bye. Pittsburgh’s veterans should be able to handle this Browns team starting a rookie quarterback. **PICK: Steelers -6.5**

**LOS ANGELES CHARGERS (-3.5) at MIAMI DOLPHINS:** The Bolts have faltered since a strong start to the season. But the Dolphins cannot be trusted. **PICK: Chargers -3.5**

**NEW ENGLAND PATRIOTS (-3.5) at NEW ORLEANS SAINTS:** The Pats might have a little bit of a come down after such a big win last weekend. The Saints will be competitive in a loss. **PICK: Saints +3.5**

**SEATTLE SEAHAWKS (-1.5) at JACKSONVILLE JAGUARS:** The Jags keep winning but they really should’ve lost on Monday night. The Seahawks rank towards the top of the league in DVOA and point differential. **PICK: Seahawks -1.5**

**ARIZONA CARDINALS at INDIANAPOLIS COLTS (-8.5):** The Cardinals are frauds. The Colts are legit. **PICK: Colts -8.5**

**LOS ANGELES RAMS (-6.5) at BALTIMORE RAVENS:** The Rams are ready to roll a bad Baltimore defense. **PICK: Rams -6.5**

**DALLAS COWBOYS (-3) at CAROLINA PANTHERS:** The Panthers haven’t been easy to predict but the Cowboys’ offense is cooking and Carolina could struggle to keep up. **PICK: Cowboys -3**

**TENNESSEE TITANS at LAS VEGAS RAIDERS (-3.5):** Geno Smith has stunk so bad this season. **PICK: Titans +3.5**

**SAN FRANCISCO 49ERS at TAMPA BAY BUCCANEERS (-3.5):** Hard to bet against Baker Mayfield right now. **PICK: Buccaneers -3.5**

**CINCINNATI BENGALS at GREEN BAY PACKERS** **(-14.5):** Watch Joe Flacco mess around and come close to beating the Packers again this season. **PICK: Bengals +14.5**

**DETROIT LIONS at KANSAS CITY CHIEFS (-2.5):** The Lions have been on fire since Week 1. The Chiefs have been suspect and are playing on a short week. **PICK: Lions +2.5**

**BUFFALO BILLS (-3.5) at ATLANTA FALCONS:** The Bills are going to bounce back after last week’s loss. Michael Penix can’t keep up with Josh Allen. **PICK: Bills -3.5**

**CHICAGO BEARS at WASHINGTON COMMANDERS** **(-4.5):** The Bears are going to be motivated to get their get-back after losing to Washington last season. But they’ll come up just short on a missed game-winning field goal attempt. **PICK: Bears +4.5**

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