What is the team news?
Defenders Cristian Romero, Ben Davies and Destiny Udogie all remain sidelined after missing Sunday’s Premier League defeat to Aston Villa.
Dominic Solanke is still continuing his recovery from a minor surgical procedure while Yves Bissouma and Kota Takai remain out along with Radu Dragusin, James Maddison and Dejan Kulusevski.
The latter five are ineligible for the league stage of the Champions League anyway, as is Mathys Tel.
Our former defender Eric Dier has been ruled out for Monaco after picking up a hamstring injury.
Paul Pogba, Lukas Hradecky, Vanderson and Lamine Camara are also out for the hosts, while the game may come too soon for Christian Mawissa.
Who is the referee?
Italian official Marco Guida will take charge of the game on Wednesday, assisted by Giorgio Peretti and Giuseppe Perrotti.
Simone Sozza will be the fourth official, with Aleandro Di Paolo and assistant Daniele Chiffi on VAR duties.