Chelsea head coach Enzo Maresca has made 10 changes to his starting lineup for Wednesday's Champions League fixture against Ajax.
With Sunderland to come in the Premier League on Saturday, the Italian has taken the opportunity to make widespread alterations to try to avoid as many muscle injuries as possible.
Romeo Lavia is the only player to retain his place from the win over Nottingham Forest last weekend, and the Belgian will be partnered by the returning Enzo Fernandez.
Marc Guiu is rewarded for two lively appearances from the substitutes' bench with his first Chelsea start of the season, with Estevao Willian, Facundo Buonanotte and Jamie Gittens providing the support.
Moises Caicedo is surprisingly being used as a right-back, while Wesley Fofana makes his first start in almost a month in the centre of defence.
Jorrel Hato also starts for a Champions League game for Chelsea for the first time versus his former club, and goalkeeper Filip Jorgensen makes just his second start of the campaign.
Ajax manager Johnny Heitinga pictured on October 18, 2025
Liverpool loanee starts for Ajax against Chelsea
Meanwhile, Johnny Heitinga has opted to hand a first Ajax start to Liverpool loanee James McConnell.
Former Manchester United forward Wout Weghorst is one of the players to retain his place from the defeat to AZ Alkmaar and will lead the line.
Seventeen-year-old defensive midfielder Jorthy Mokio, who has made three starts this campaign, drops down to the substitutes' bench.
Chelsea XI: Jorgensen; Caicedo, Fofana, Adarabioyo, Hato; Lavia, Fernandez; Estevao, Buonanotte, Gittens; Guiu
Subs: Sanchez, Merrick, James, Acheampong, Chalobah, Cucurella, Walsh, Santos, Neto, Garnacho, Kavuma-McQueen, George
Ajax XI: Pasveer; Rosa, Itakura, Sutalo, Baas; McConnell, Gloukh, Taylor; Moro, Weghorst, Godts
Subs: Jards, Heerkens, Gaaei, Regeer, Edvardsen, Klaassen, Konadu, Mokio, Fitz-Jim, Alders, Bounida
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