Wilson joined the Hammers as a free agent on a one-year contract over the summer after leaving Newcastle United, where he turned down the option of a new deal on vastly reduced terms.
But Nuno has yet to use the former England international in his three matches in charge so far, leaving the 33-year-old on the bench despite West Ham chasing a goal in their 2-0 defeat at home to Brentford on Monday.
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However, when it was put to the Portuguese that he was ignoring Wilson because he is on an incentive-based, play-as-you-play style deal, he retorted: "Oh, please. Come on, eh?
"Come on. I don't even know that. You think I'm this kind of person? Do I think that? No. Maybe if you knew me better, maybe we don't have to speak about that.
"It's nothing more than a decision. There's nothing there. This speculation doesn't help. You think I think about all these aspects when I have to make a decision to help the team? I don't know.
"I've been here three games. There's a future for him. There's a future for everybody.
"Especially when you are in such a tough situation. We need all of them."