Mac Jones will again be the starting quarterback for the San Francisco 49ers after Brock Purdy was ruled out of Sunday’s game against the Houston Texans due to his toe injury.
It will mark the fourth straight game and sixth overall that Purdy has missed this season. He was injured in a Week 1 victory over the Seattle Seahawks and aggravated the toe during a Week 4 loss to the Jacksonville Jaguars.
49ers ruled out Brock Purdy (toe) and Ricky Pearsall (knee) for Sunday’s game at Houston.
Mac Jones starts again.
— Adam Schefter (@AdamSchefter) October 24, 2025
San Francisco is 4-1 when Jones starts this season. He has passed for 1,404 yards, six touchdowns and four interceptions.
Receiver Ricky Pearsall (knee) will miss his fourth straight game. Also ruled out on Friday were center Jake Brendel (hamstring) and defensive ends Bryce Huff (hamstring) and Yetur Gross-Matos (knee/hamstring).
Cornerback Deommodore Lenoir (quadriceps), linebacker Luke Gifford (hamstring) and offensive lineman Spencer Burford (knee) are questionable.
–Field Level Media
More San Francisco 49ers content from Sactown Sports
Although they have dealt with a devastating amount of injuries to their core, the San Francisco 49ers are off to a 5-2 start to the 2025 regular season.
During Tuesday morning’s edition of The Carmichael Dave Show with Jason Ross, former NFL quarterback Sean Salisbury joined the show to share his reaction to the 49ers’ win over the Atlanta Falcons, explain why this year may be head coach Kyle Shanahan’s best work yet, and much more.
Be sure to listen to and watch the entire interview with former NFL QB Sean Salisbury right here or on the Sactown Sports 1140 YouTube page.
Former NFL QB on why 49ers HC Kyle Shanahan has impressed him thus far
Upcoming San Francisco 49ers Schedule
Sunday, October 26th – @ Houston Texans – 10:00 AM PT
Sunday, November 2nd – @ New York Giants – 10:00 AM PT
Sunday, November 9th – vs. Los Angeles Rams – 1:25 PM PT
Sunday, November 16th – @ Arizona Cardinals – 1:05 PM PT
Monday, November 24th – vs. Carolina Panthers – 5:15 PM PT
Thank you for readingSactownSports.com. Follow us onTwitterandGoogle News, and subscribe to ourYouTubechannel.