Cole Palmer’s absence is the big one, of course, but he’s missed so much of this season that the team has had time to adjust.
Wesley Fofana played ninety minutes in midweek after a while out so might not be ready for more. Garnacho should keep his place ahead of Jamie Gittens and Tosin Adarabioyo is likely to pip Acheampong, but it’s close in both cases.
Off the top of my head: Sanchez, James, Chalobah; Tosin, Cucurella, Caicedo; Enzo, Garnacho, João Pedro; Neto, Guiu.
The other alternative is dropping Garnacho for Roméo Lavia and playing a three-man midfield with João Pedro a little wider.