Launched by the Palestine Solidarity Campaign, it calls on people to sign an open letter to FA chair Debbie Hewitt, Aston Villa chair Nassef Sawiris and UEFA president Aleksander Čeferin demanding the match be cancelled.
The open letter also calls for an end to Israel's membership of international footballing bodies.
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If the FA and UEFA do not work together to cancel the match, campaigners say Aston Villa must refuse to play, the letter says.
The match has come in for major scrutiny after Maccabi fans were banned from attending the match in Birmingham, with police deeming the game "high-risk".
The UK Government attempted to overturn the ban but Maccabi Tel Aviv have since said they will not sell tickets to fans for the match.
The letter says Israel cannot be allowed to "cynically present itself as a normal country".
It states: "I am writing to demand immediate action is taken to ensure that Aston Villa’s match with Maccabi Tel Aviv on 6 November does not go ahead. The FA and UEFA must work to cancel the match and expel Israel from membership from international footballing bodies. If this does not happen, Aston Villa FC must refuse to host and play the match.
(Image: Mouneb Taim/Anadolu via Getty Images)
"Israel’s genocide against Palestinians in Gaza has killed many tens, if not hundreds of thousands of Palestinians, including many hundreds of Palestinian footballers. It has annihilated Gaza’s footballing infrastructure such as stadiums, training facilities and pitches.
"In the occupied West Bank, Israel has systematically targeted Palestinian sports infrastructure, while its military invasions of towns and refugee camps have killed scores of Palestinian footballers. Last year, Israeli forces deliberately destroyed Jenin Municipal Football Stadium during their military offensive on the city.
"Allowing Israeli football teams to compete in international competitions sanitises this horrific violence and allows Israel to cynically present itself as a normal country, obscuring the truth that it is carrying out a genocide in Gaza, and imposing a regime of settler-colonialism, military occupation and apartheid against Palestinians.
"I am sending this letter to the FA, UEFA and Aston Villa FC to ask that each takes action respectively to ensure that the match does not go ahead."
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The letter highlights how Maccabi fans have a "long history of violence" which was exemplified last year in Amsterdam when the club played Ajax. This incident ultimately led local authorities to conclude it would not be safe to host Maccabi fans in Birmingham.
A photographer who captured violent scenes in the Dutch capital that night told The National she could understand why a ban had been put in place, adding that she disagreed with Keir Starmer’s assessment that this was “wrong”.
In recent days, UK Sport Secretary Lisa Nandy has been called out for “grossly misleading” remarks she made in the Commons about the ban on Maccabi Tel Aviv fans.
She falsely told MPs that it was “unprecedented” for away fans to be banned from a football match in the UK.
In fact, away fans being banned from attending a football match due to safety fears is a relatively common occurrence. For example, for the entirety of the 2023/2024 Scottish premiership season, Celtic and Rangers banned each others’ fans from attending away matches.
To sign the petition, click here.