Pittsburgh Steelers OG Isaac Seumalo suffered a pectoral injury late in the game against the Indianapolis Colts and has been ruled out for the rest of the game, per the CBS broadcast.
Steelers senior director of communications Burt Lauten tweeted that Seumalo was ruled out due to a pec injury.
#Steelers G Isaac Seumalo has a pec injury and is OUT for the rest of today's game.
— Burt Lauten (@SteelersPRBurt) November 2, 2025
Seumalo also suffered a pectoral injury in Week 8 against the Green Bay Packers but entered today’s game without any injury designation despite being limited in practice early in the week. With Seumalo out, the Steelers replaced him with Spencer Anderson, which limits their use of their jumbo package.
Anderson filled in for Seumalo last week for most of the second half when he exited against Green Bay and had a solid performance.
Additionally, LB Patrick Queen suffered an injury in the fourth quarter of Pittsburgh’s Week 9 game against the Indianapolis Colts. Queen hit QB Daniel Jones on a third-down throw and was slow to get up, and per The Athletic’s Mike DeFabo, he made his way to the blue medical tent after the play.
DeFabo noted Queen was grabbing his right arm/shoulder area.
Patrick Queen is holding his right arm/ shoulder area after hitting Daniel Jones as he threw on third down. He's going into the medical tent.
— Mike DeFabo (@MikeDeFabo) November 2, 2025
Both are key starters for the Steelers, and it’s worrisome that Seumalo suffered a pec injury for the second week in a row. The Steelers have a solid replacement in Anderson, but Seumalo is a veteran leader for the offensive line and the offensive line is a group that’s been developing nicely throughout the season and has turned into a strength for the Steelers. The jumbo package has also been highly successful, and Seumalo’s injury could limit how much the Steelers use it.
Queen hasn’t missed a game yet since signing with the Steelers ahead of last season, and has started every game he’s been a member of the team. The Steelers currently don’t have Cole Holcomb available today due to an illness, so Carson Bruener and Malik Harrison are the team’s backup linebackers.
Mike Tomlin will likely give a status update on both after the game.
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