Mahomes took over at his own 47-yard-line in the first quarter after Kansas City's defense put up a fourth-down stop on the Bills' second possession of the evening. The drive bled into the second quarter when wide receiver Rashee Rice took a direct snap and crossed over into the end zone.
Buffalo also capitalized on a fourth-down stop late in the second quarter. After Bishop broke up two passes that left the Chiefs short three yards of the line of gain, quarterback Josh Allen retook the field.
At the Bills' 39-yard-line, running back James Cook III rushed up the middle, looking to capitalize on the open space ahead of him. After his initial surge forward, Cook was taken down after a 16-yard gain. He and wide receiver Khalil Shakir fought for the next first down, which forced Kansas City to use its first timeout of the half.
Out of the timeout, Allen found tight end Dawson Knox who made the catch and charged toward the end zone. Just before extending and diving forward to add another touchdown on the board, the veteran was pushed and stepped out of bounds. Cook picked up two of the remaining three yards, causing the Chiefs to use a second timeout, and Allen capped it off with a one-yard rushing touchdown.
The Bills were 4-0 in 2025 when scoring on their first possession, and Sunday's win extended that record to 5-0.
The Bills needed 14 yards to convert after Cook was taken down four yards behind the line of scrimmage deep into Buffalo's first drive. On second down, Allen connected with wide receiver Curtis Samuel on a short pass for a six-yard gain. Allen targeted Kincaid on third-and-eight on the next snap as Kincaid was wide open backtracking into the right corner of the end zone. The 23-yard completion put Buffalo up 7-0 to start the evening.
Kincaid also sparked the second scoring drive for the Bills.
In the second quarter after Kansas City took the lead with a field goal, making it 10-7, Buffalo was pushed back 10 yards that forced it into a second-and-13 situation at its own 45-yard-line. Allen stepped back and had time for Kincaid to reach his spot and the quarterback hit the tight end in motion at the Chiefs 42-yard-line. Though the spot was enough to convert, Kincaid continued, running towards the left sideline all the way to the eight-yard-line. This set the Bills up for their second touchdown and second lead of the evening, which was recorded by running back Ty Johnson.
Just how the defense set up Buffalo's third score of the game, defensive end Michael Hoecht paved the way for the team's fourth while also helping shut out Kansas City in the third quarter completely.
On third-and-six, pressure closed in on Mahomes, forcing him to get the ball out as quickly as possible. Hoecht reached high to tip and deflect the pass, causing the ball to eventually hit the ground. After an unsuccessful debate on the sidelines with head coach Andy Reid as to whether he can challenge an intentional grounding call given to Mahomes after the play, the Chiefs had to convert on third-and-16. Hoecht stopped that conversion attempt with Rousseau quickly as both were awarded with a partial sack, pushing Kansas City back another eight yards as the punt unit ran out.