The Reds and the Spanish outfit lock horns again on Tuesday night at Anfield for matchday four of the Champions League's league phase.
Frequent opponents in recent years, they actually had little history when paired against each other in the tournament's last-16 phase back in 2009.
In fact, the return leg in L4 was just their third encounter.
Already 1-0 up on aggregate from their trip to the Santiago Bernabeu, Rafael Benitez's team were a juggernaut on home soil.
Fernando Torres scored with 16 minutes on the clock and Steven Gerrard helped himself to two goals either side of half-time.
Andrea Dossena put the seal on a 4-0 victory and an iconic European occasion near the end.
Amid it all, Spearing - brought on from the bench midway through the second half - lived out his own fairy tale.
"Anfield debut, an unbelievable occasion for me and my family," he recalled in an interview with Liverpoolfc.com.
"I joined the club at seven. And to come and make a debut at Anfield, not a first experience of it but the first time on the pitch in a competitive game, [for it] to be against the giants of Real Madrid, you can't quite top it and it was a dream come true.
"They are two monster clubs and I knew exactly who I played for, Liverpool Football Club and what comes with the weight of the badge.
"Playing against Real Madrid, the history of that club, and two giants in European football. To have them here and to have an opportunity at 18, 19 years old to be involved in that fixture, that alone was a bonus for me. Finding out I was involved in the squad, I'd have taken that all day, maybe not even make an appearance on the pitch.
"But for the manager to give me 25 minutes and be able to play in front of the Kop and for the Kop to sing my name, the whole dream as a young boy as a Liverpool fan was made on that night."
Tuesday's showdown will be the 13th clash of the clubs, who boast six and 15 European Cup triumphs respectively.
In edition No.12, Arne Slot's men got the better of Real when they faced off at Anfield almost 12 months ago in the competition.