Chaos erupted in Week 9 of the 2025 NFL season. We saw big favorites like the Green Bay Packers, Indianapolis Colts and Detroit Lions all go down. Meanwhile, the Buffalo Bills took down the Kansas City Chiefs and the Chicago Bears survived a huge scare from the Cincinnati Bengals.
It’s a reminder that anything can happen on any given Sunday and the NFL schedule this week could be no different. With that in mind, let’s dive into our NFL Week 10 predictions.
Related: NFL Week 10 Power Rankings, see Risers an Fallers after Chaotic Week 9
Denver Broncos 27, Las Vegas Raiders 17
NFL Week 10 Predictions
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The good news for the Las Vegas Raiders in this Thursday Night Football matchup versus the Denver Broncos is that Brock Bowers is healthy. It’s an enticing matchup for the All-Pro, as one of the few vulnerabilities on this Broncos defense is its pass coverage versus tight ends (482 receiving yards and 13.0 yards per reception allowed). The good fortune ends there for Las Vegas. Denver comes into Week 10 with a league-high 40 sacks and the Raiders offensive line can’t hold up in pass protection. On top of that, Las Vegas has allowed 122.3 rushing yards per game in its last six contests. The Broncos should win this one comfortably.
Indianapolis Colts 28, Atlanta Falcons 20
NFL Week 10 Predictions
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The Atlanta Falcons defense is going to try to heat up Daniel Jones, as evidenced by the second-highest blitz rate (33.9 percent) in the NFL. However, Jones has carved up the blitz this season and the Indianapolis Colts offensive line can hold up well in pass protection. That’s not to mention the fact that Jonathan Taylor is facing a Falcons run defense that has allowed 141.2 rush ypg and 4.6 yards per carry in the last five games. Bijan Robinson’s big-play ability gives Atlanta a chance against Indianapolis, but the Colts are the better team and well equipped to handle what the Falcons throw at them.
Chicago Bears 31, New York Giants 24
NFL Week 10 Predictions
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This could’ve been one of the most entertaining games on the NFL schedule this week if not for the season-ending injuries to Cam Skattebo and Malik Nabers. It’s because of those absences that Jaxson Dart won’t have the weapons on this New York Giants offense to exploit a Chicago Bears defense that has allowed 20 passing touchdowns and a 5.1 yards-per-carry average to opponents this season. Instead, Chicago gets to have the big advantage as New York has allowed 150 rush ypg and 5.5 yards per carry this season, all the while allowing 231.1 passing yards and 1.7 passing touchdowns per game to opposing quarterbacks.
Buffalo Bills 38, Miami Dolphins 20
NFL Week 10 Predictions
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The Thursday Night Football matchup between the Miami Dolphins and Buffalo Bills a few weeks ago was closer than expected. We don’t anticipate that being the case in this Week 10 rematch. Miami waved its white flag on the season with the Jaelan Phillips trade, and that will make a bottom-five defense even worse. Josh Allen might not have to do a ton through the air in this game, since James Cook can run for days versus a Dolphins defense that is allowing 145.6 rushing yards and 1.1 rushing touchdowns per game.
Minnesota Vikings 23, Baltimore Ravens 20
NFL Week 10 Predictions
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This is one of the most intriguing matchups in Week 10. After a brutal four-game stretch, allowing a 123.1 QB rating, 26.5 points, and 353.8 total yards per game, the Minnesota Vikings defense rebounded with a great performance this past Sunday in Detroit. Likewise, the Baltimore Ravens defense went from an abysmal five-game stretch (35.4 PPG and 408.8 total YPG allowed) to surrendering just 13 points and 315 total yards per game in their last three contests. It’s anyone’s guess what version of either defense we get on Sunday. With Minnesota hosting this matchup and having a better track record defensively, we think the Vikings win a back-and-forth game.
Cleveland Browns 17, New York Jets 13
NFL Defense Rankings
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If there was a realistic scenario where neither team could win this game, we would’ve picked that outcome. The Cleveland Browns passing game with Dillon Gabriel under center is about as predictable and easy to defend as a high school offense. On the other side, the one thing the New York Jets do really well is run the football, but they face a defense that has allowed just a 3.6 yards-per-carry average this season. We’d advise Jets and Browns fans to watch something else or find something better to do on Sunday, because this game isn’t worth it.
New England Patriots 20, Tampa Bay Buccaneers 17
NFL Week 10 Predictions
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Given the ineffectiveness of the New England Patriots rushing attack (3.9 yards per carry), they are almost better off not even trying to establish the run against the Tampa Bay Buccaneers (3.9 ypc allowed). Fittingly, the same could be said for Tampa Bay (3.8 ypc) against the Patriots run defense (75.4 rush ypg allowed). Both defenses have also fared well versus the pass in recent weeks, but New England might have a bit more success on Sunday considering that Tampa Bay is thin at receiver right now. This is one of our favorite games on the NFL schedule for Week 10 and the winner could be put in a much better spot for the No. 1 seed in their conference.
Related: NFL Defense Rankings 2025
Carolina Panthers 24, New Orleans Saints 17
NFL Week 10 Predictions
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Feed Rico Dowdle. That was the Carolina Panthers in their win against Green Bay and it should carry over into a Week 10 matchup versus a defense that is on pace to allow over 2,000 rushing yards and a 4.0 yards-per-carry average this season. As for the New Orleans Saints, they’ll have one wide receiver taken away by Jaycee Horn and we don’t trust rookie quarterback Tyler Shough to perform well against Ejiro Evero’s defense.
Jacksonville Jaguars 23, Houston Texans 17
NFL Defense Rankings
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The Houston Texans should win this game if C.J. Stroud clears the NFL concussion protocol, but that is far from a given. Stroud suffered a concussion after a significant hit in Week 9 and was ruled out for the remainder of the game against the Denver Broncos. His return status remains uncertain as he continues through the concussion protocol. Even without Stroud, the Texans defense will make it extremely difficult for Trevor Lawrence in a matchup where the Jacksonville Jaguars might very well be without Brian Thomas Jr. and Travis Hunter (IR). For now, Davis Mills is anticipated to start for the Texans in Week 10, and they are likely to lose another close game with him in Stroud’s place.
Seattle Seahawks 27, Arizona Cardinals 14
NFL Week 10 Predictions
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Similar to the Bills vs Dolphins game, we think the close score in the last meeting between the Arizona Cardinals and Seattle Seahawks was more about playing on Thursday Night Football. It’s also worth noting from that matchup that Seattle outgained Arizona by 131 total yards on the same number of plays. We expect a defensive clinic from the Seahawks, especially with Kyler Murray expected to start in Week 10.
Los Angeles Rams 28, San Francisco 49ers 21
NFL Week 10 Predictions
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It took a missed field goal, a missed extra-point attempt, and a lost fumble at the 1-yard line for the Los Angeles Rams to lose in overtime to the San Francisco 49ers in their last meeting on Thursday Night Football. San Francisco’s defense also still had a healthy Fred Warner and Bryce Huff in that game. The 49ers simply don’t have the bodies to beat Los Angeles twice in a season, that is as long as the Rams don’t give the game away to their rival.
Detroit Lions 42, Washington Commanders 17
NFL Week 10 Predictions
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The Washington Commanders don’t have a pass rush, a viable receiving corps, nor Jayden Daniels. What they do have is one of the league’s worst secondaries that just lost Marshon Lattimore (ACL) for the season. On the other side of the field is a Detroit Lions team looking to rebound after an ugly home loss to Minnesota. Dan Campbell and Co. will not let up on the Commanders in this one. It’ll get ugly pretty quickly.
Pittsburgh Steelers 23, Los Angeles Chargers 20
NFL Defense Rankings
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It took six takeaways for the Pittsburgh Steelers to beat Indianapolis by 7 points, similar to this team’s victory in September over New England when the Patriots turned it over 5 times with two of those coming inside the Steelers’ 2-yard line. With all that said, this Los Angeles Chargers offense without Joe Alt at left tackle is painful to watch. Aaron Rodgers and Jaylen Warren will do just enough on Sunday Night Football for the Steelers to beat Los Angeles.
Philadelphia Eagles 34, Green Bay Packers 24
NFL Week 10 Predictions
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The Green Bay Packers don’t have the cornerbacks who can handle one-on-one coverage against A.J. Brown and DeVonta Smith. Nor does Green Bay have the interior defense, as evidenced by the 5.0 yards-per-carry average allowed in the last two games, to handle Saquon Barkley. Plus, the Philadelphia Eagles just added edge rusher Jaelan Phillips ahead of the NFL trade deadline while Green Bay lost standout tight end Tucker Kraft to an ACL tear. It’s very bad timing and an even worse matchup for the Packers on Monday Night Football. Philadelphia can win this by double-digit points, assuming it doesn’t get in its own way.
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Matt Johnson is Senior Editor of NFL and College Football for Sportsnaut. His work, including weekly NFL and college ... More about Matt Johnson