Ahead of Week 10 of the 2025 NFL season, we break down the three players with the shortest odds to score a touchdown, all of whom are prolific running backs
08:00 ET, 08 Nov 2025
Buffalo Bills quarterback Josh Allen hands the ball off to running back James Cook
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The Buffalo Bills rank second in the NFL with 16 rushing touchdowns this year(Image: Photo by Lauren Leigh Bacho/Getty Images)
Another weekend of football is around the corner, with 12 teams in action across 24 games on Sunday, before the Green Bay Packers host the Philadelphia Eagles on Monday night to close out Week 10.
Many of the NFL’s premier touchdown scorers will feature on Sunday or Monday night, including the league leaders in rushing TD (Jonathan Taylor, 12) and receiving TD (Davante Adams, 8).
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It’s important to note that this list does not include quarterbacks who may throw a touchdown pass, rather skill position players who will either run for or catch a touchdown.
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Ahead of this weekend’s action, let’s take a look at the players who have the best odds to find the end zone in Week 10.
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Jonathan Taylor, RB, Indianapolis Colts
It’s only right that the NFL’s touchdown leader is the most likely player to score a touchdown in Week 10, with -320 odds to find the end zone when the Indianapolis Colts face the Atlanta Falcons in Berlin, Germany on Sunday morning.
Taylor and the Indianapolis offense looked unstoppable this season until the Steelers defense stepped up to stifle them in Week 9, limiting the star running back to a season-low 45 rushing yards.
Prior to Week 9, Taylor scored 10 touchdowns in four weeks.
James Cook, RB, Buffalo Bills
Cook leads all NFL running backs with 108.4 rushing yards per game this year, and tied-for-fourth with his quarterback Josh Allen with seven rushing touchdowns.
Buffalo Bills running back James Cook celebrates after beating the Carolina Panthers
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James Cook ran for a career-high 216 yards and two scores against the Panthers in Week 8(Image: Photo by Matt Kelley/Getty Images)
In Week 10, Cook and the Bills travel to face AFC East division foe the Miami Dolphins, who have done little to stop opposing running backs this season. As a result, Buffalo’s running back is -195 to score a touchdown.
In eight career games against Miami, Cook has scored seven total touchdowns.
Christian McCaffrey, RB, San Francisco 49ers
McCaffrey has carried the 49ers’ offense without the likes of Brock Purdy, George Kittle, and Brandon Aiyuk for large stretches this season. The 2023 Offensive Player of the Year leads his team in total rushing yards (596), receiving yards (626) and touchdowns (eight).
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In Week 10, McCaffrey is priced at -165 to score a touchdown against NFC West rival the Los Angeles Rams.
In five career games against the Rams, McCaffrey has six total touchdowns, including four on the ground and two through the air.
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