This article will focus on three players at each position using DraftKings’ pricing for the Sunday 1 p.m. slate. We will provide three pricing options: high, medium, and low, based on matchups and game theory, from top to bottom. Now that we’ve taken care of the housekeeping, let’s move on to week 10.
Quarterbacks:
Sep 18, 2025; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) runs against the Miami Dolphins in the second half at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images
QB Josh Allen, Buffalo Bills ($7,000)
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Allen has a decent matchup this week on the road in Miami. He is averaging almost 23 fantasy points per game over the last five games. Vegas has this game with the highest projected total on the slate.
QB Jared Goff, Detroit Lions ($5,900)
Goff has a great matchup this week on the road against the Commander. Washington is allowing almost 25 fantasy points per game to opposing QBs over the last four games. The Lions should put up some points this week!
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QB Jacoby Brissett, Arizona Cardinals($4,600)
Brissett has a good matchup this week on the road in Seattle. He is averaging almost 23 fantasy points per game this year. He might be a lock this week. Consider Brissett a value play!
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Running Backs:
Oct 19, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) celebrates after a touchdown during the second quarter against the Atlanta Falcons at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images
RB Christian McCaffrey, San Francisco 49ers ($9,000)
McCaffrey has a decent matchup at home against Los Angeles. He is averaging almost 29 fantasy points per game against the Rams over the last four games. Vegas has this game with the highest projected total on the slate.
James Cook III, Buffalo Bills ($7,500)
Cook has a good matchup on the road in Miami. He is averaging more than 20 fantasy points per game against the Dolphins over the last three games. Consider Cook a GGP play!
RB D’Andre Swift, Chicago Bears ($6,100)
Swift has a great matchup at home this week against New York. The Giants have allowed almost 37 fantasy points per game to the RB1 position over the last two games. Consider Swift a GGP Play!
Wide Receivers:
Detroit Lions wide receiver Amon-Ra St. Brown celebrates the 31-23 win over the Tampa Bay Buccaneers
Detroit Lions wide receiver Amon-Ra St. Brown celebrates the 31-23 win over the Tampa Bay Buccaneers in the NFC divisional round at Ford Field in Detroit on Sunday, Jan. 21, 2024. His hair is dyed blue. | Junfu Han / USA TODAY NETWORK via Imagn Images
WR Amon-Ra St. Brown, Detroit Lions ($8,400)
St. Brown has a good matchup this week on the road in Washington. He is averaging almost 20 fantasy points per game over the last five games. Consider St. Brown a GPP play.
WR Jaylen Waddle, Miami Dolphins ($6,400)
Waddle has a good matchup this week at home against the Bills. He is averaging more than 15 fantasy points per game over the last five games. The Dolphins’ offense is still shaky, but he’s been involved. Consider Waddle a GGP play!
WR Marvin Harrison Jr., Arizona Cardinals ($5,300)
Harrison has a good matchup on the road in Seattle. Last week, he had 7 receptions, 96 receiving yards, and a TD. I’m going back to the well this week. Consider Harrison a value play!
Tight Ends:
Nov 3, 2025; Arlington, Texas, USA; Arizona Cardinals tight end Trey McBride (85) celebrates scoring a touchdown against Arizona Cardinals wide receiver Michael Wilson (14) in the second half at AT&T Stadium. Mandatory Credit: Jerome Miron-Imagn Images
TE Trey McBride, Arizona Cardinals ($6,000)
McBride has a decent matchup this week on the road in Seattle. He is averaging almost 17 fantasy points per game against the Seahawks over the last four games. Consider McBride a GPP play!
TE George Kittle, San Francisco 49ers ($4,500)
Kittle has a decent matchup this week at home against Los Angeles. He could fly under the radar because he hasn’t done much since coming back from a hamstring injury that has kept him out most of the season. Consider Kittle a man of interest!
TE Dalton Schultz, Houston Texans ($3,600)
Schultz has a great matchup this week at home against the Jaguars. He is averaging almost 12 fantasy points per game over the last four games. Consider Schultz a value play!
Defense:
Oct 20, 2025; Detroit, Michigan, USA; Detroit Lions defensive end Aidan Hutchinson (97) takes the field before the game at Ford Field. Mandatory Credit: David Reginek-Imagn Images
Detroit Lions DEF ($3,400)
The Lions’ defense has forced 7 INTs, 15 sacks, and 2 fumbles over the last five games. They should be able to control the game on the road in Washington.
Houston Texans DEF ($3,100)
The Texans’ defense is playing well. They are averaging almost 12 fantasy points per game over the last five games. If QB C.J. Stroud is ruled out, I would be more interested in Jacksonville.
Jacksonville Jaguars DEF ($2,600)
The Jaguars’ defense has struggled the last couple of games, but if QB Davis Mills starts, they could be a lock. Consider the Jaguars a Boom or Bust play!
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