Helen Bleazard’s side are yet to concede a goal in the competition, winning each of their four games in it so far.
In the qualifying group stage, they defeated Bournemouth Sports 3-0 and Moneyfields 2-0, both at home, before a 6-0 win at Ascot.
The first knockout round saw them edge past QPR, beating them 1-0 thanks to a Kenni Thompson penalty with 13 minutes left to play.
The Grecians, meanwhile, defeated Portishead 3-0 away from home, before a 5-2 win over Southampton PGA and a 5-0 victory over Abingdon United, both at home.
The first knockout round saw them host Fulham, whom they defeated 4-2.
The Cherries have faced Exeter already this season in the league, with the sides playing out a 1-1 draw at the Ringwood Community Hub.
Former Grecian Jenna Markham scored a dramatic late equaliser to rescue a late point for the Cherries, after Sophie Gillies had opened the scoring for the visitors after ten minutes.
AFC Bournemouth travel to Coach Road to face Exeter City in the WNL League Cup on Sunday, November 9, kick off at 2pm.